Goad M E, Whitaker M S
Biology Division, Oak Ridge National Laboratory, TN 37841.
Lab Anim Sci. 1989 Mar;39(2):137-41.
Male and female 16 to 18 month old C3Hf/Bd mice in a dermal carcinogenicity study were moribund or died at earlier time points than the expected 24 to 30 months. Clinical signs observed in both treated and control animals included dyspnea, lethargy, and death. Lesions seen in treated as well as control mice were cardiomegaly with myocardial degeneration and necrosis, hydrothorax and pulmonary edema, and ascites and chronic passive congestion of the liver. Mice were negative for serologic, bacteriologic and microscopic evidence of viruses, bacteria and protozoa which can induce heart lesions. Possible causes of the cardiomyopathy include metabolic, degenerative, genetic or undetermined infectious disease.
在一项皮肤致癌性研究中，16至18月龄的C3Hf/Bd雄性和雌性小鼠比预期的24至30个月更早出现濒死状态或死亡。在治疗组和对照组动物中观察到的临床症状包括呼吸困难、嗜睡和死亡。在治疗组和对照组小鼠中均可见的病变有心增大伴心肌变性和坏死、胸腔积液和肺水肿、腹水以及肝脏慢性被动性充血。小鼠的病毒、细菌和原生动物的血清学、细菌学和显微镜检查证据均为阴性，这些病原体可诱发心脏病变。心肌病的可能原因包括代谢性、退行性、遗传性或不明原因的感染性疾病。
