具有改善的热稳定性和免疫原性的氧化铝包封疫苗制剂。
Alumina-encapsulated vaccine formulation with improved thermostability and immunogenicity.
作者信息
Zhou Hangyu, Wang Guangchuan, Li Xiao-Feng, Li Yaling, Zhu Shun-Ya, Qin Cheng-Feng, Tang Ruikang
机构信息
Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou 310027, China.
出版信息
Chem Commun (Camb). 2016 May 11;52(38):6447-50. doi: 10.1039/c6cc02595a. Epub 2016 Apr 21.
Developing vaccine formulations with excellent thermostability and immunogenicity remains a great challenge. By in situ encapsulating a live-attenuated strain of human enterovirus 71 (EV71) in alumina, we obtained a robust vaccine formulation named EV71@NanoAlum, which features significantly enhanced thermostability and immunogenicity. This attempt follows a material-based tactic for vaccine improvement.
开发具有出色热稳定性和免疫原性的疫苗制剂仍然是一项巨大挑战。通过将人肠道病毒71型（EV71）减毒株原位封装在氧化铝中，我们获得了一种名为EV71@NanoAlum的强大疫苗制剂，其具有显著增强的热稳定性和免疫原性。这种尝试遵循了一种基于材料的疫苗改进策略。
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