一种新型内镜胃造口闭合器的研究：一项在体和离体动物实验。
A novel occluder for endoscopic closure of gastrotomy: an ex vivo and in vivo animal study.
机构信息
Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea,Incheon, Korea.
Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
出版信息
Endoscopy. 2016 Aug;48(8):766-70. doi: 10.1055/s-0042-105559. Epub 2016 Apr 21.
BACKGROUND AND AIMS
We evaluated the feasibility of a novel occluder for endoscopic closure of natural orifice transluminal endoscopic surgery (NOTES) gastrotomy.
METHODS
The occluder is a self-expandable, membrane-covered, metal structure for endoscopic delivery through gastrointestinal (GI) wall defects. The procedure time and air-tightness of endoscopic closure for a 12-mm perforation were compared for a through-the-scope clip group and an occluder group in an ex vivo animal study. The feasibility and safety of the occluder for the closure of NOTES gastrotomy were also evaluated in an in vivo animal study.
RESULTS
In the ex vivo study, the median procedure time for closure was significantly shorter and the minimum air-leakage pressure was significantly greater in the occluder group than in the endoclip group. In the in vivo study, immediate air-tight sealing was achieved by application of the occluder and there were no serious adverse events. All animals showed spontaneous detachment of the occluder into the gastric lumen and complete healing within 4 - 8 weeks.
CONCLUSIONS
The novel occluder can provide immediate and permanent sealing for NOTES gastrotomy.
背景与目的
我们评估了一种新型封堵器用于经自然腔道内镜手术（NOTES）胃造口内镜闭合的可行性。
方法
该封堵器是一种自膨胀、膜覆盖的金属结构，可通过胃肠道（GI）壁缺损进行内镜输送。在一项离体动物研究中，我们比较了通过内镜夹组和封堵器组用于 12mm 穿孔内镜闭合的操作时间和气密性。我们还在体内动物研究中评估了封堵器用于 NOTES 胃造口闭合的可行性和安全性。
结果
在离体研究中，封堵器组的中位操作时间明显短于内镜夹组，最小漏气压力明显大于内镜夹组。在体内研究中，应用封堵器可立即实现气密密封，且无严重不良事件。所有动物均自发性地将封堵器脱入胃腔，且在 4-8 周内完全愈合。
结论
新型封堵器可为 NOTES 胃造口提供即刻和永久的密封。
Zotero 插件