Valdespino-Gómez Víctor M, Valdespino-Castillo Víctor E
Departamento de Atención a la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana Xochimilco, Ciudad de México, México.
Rev Med Inst Mex Seguro Soc. 2016 May-Jun;54(3):364-74.
More than 200 cancer susceptibility syndromes (CSS) have been recognized through performing classic epidemiologic studies and genetic linkage analysis. In most CSSs clinical conditions of the patients have been identified as well as their hereditary patterns and the predisponent genes to cancer development. Cancer hereditary identification is a useful condition, since cancer family integrants may benefit of efficient strategies in early screening and in tumor prevention strategies; this consultation is performed by oncogenetic molecular medical consultants who must be scientifically competent for Human Genetics and Cancer molecular biology domains. The oncogenetic molecular consult of patients and family relatives of cancer predisposition families is a medical service in health programs of developed and developing countries; in our country this type of medical service needs to be organized and settled to be part of the integral oncology medical service. The oncogenetic molecular consultation is a structural process of assessment and communication of the associated integral problems of the cancer inherited susceptibility in familial cancer.
通过开展经典流行病学研究和基因连锁分析，已识别出200多种癌症易感性综合征（CSS）。在大多数CSS中，患者的临床状况、遗传模式以及癌症发生的易感基因均已明确。癌症遗传鉴定是一项有益的工作，因为癌症家族成员可能会从早期筛查和肿瘤预防策略的有效方案中受益；此项咨询由肿瘤遗传分子医学顾问进行，他们必须在人类遗传学和癌症分子生物学领域具备专业素养。对癌症易感家族的患者及其亲属进行肿瘤遗传分子咨询，这在发达国家和发展中国家的卫生项目中都是一项医疗服务；在我国，这类医疗服务需要加以组织和落实，使其成为综合肿瘤医疗服务的一部分。肿瘤遗传分子咨询是对家族性癌症中癌症遗传易感性相关综合问题进行评估和沟通的结构化过程。
