从中国东部鸡群中分离出的新型重配H6N6亚型禽流感病毒的分离与基因特征分析
Isolation and genetic characterization of novel reassortant H6N6 subtype avian influenza viruses isolated from chickens in eastern China.
作者信息
Wu Haibo, Lu Rufeng, Peng Xiuming, Peng Xiaorong, Cheng Linfang, Jin Changzhong, Lu Xiangyun, Xie Tiansheng, Yao Hangping, Wu Nanping
机构信息
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China.
出版信息
Arch Virol. 2016 Jul;161(7):1859-72. doi: 10.1007/s00705-016-2861-4. Epub 2016 Apr 21.
H6 subtype avian influenza viruses (AIVs) possess the ability to cross the species barrier to infect mammals and pose a threat to human health. From June 2014 to July 2015, 12 H6N6 AIVs were isolated from chickens in live-poultry markets in Zhejiang Province, Eastern China. Phylogenetic analysis showed that these isolates received their genes from H6 and H9N2 subtype AIVs of poultry in China. These novel reassortant viruses showed moderate pathogenicity in mice and were able to replicate in mice without prior adaptation. Considering that novel reassorted H6N6 viruses were isolated from chickens in this study, it is possible that these chickens play an important role in the generation of novel reassorted H6N6 AIVs, and these results emphasize the need for continued surveillance of the H6N6 AIVs circulating in poultry.
H6亚型禽流感病毒（AIVs）具有跨越物种屏障感染哺乳动物的能力，并对人类健康构成威胁。2014年6月至2015年7月，从中国东部浙江省活禽市场的鸡中分离出12株H6N6 AIVs。系统发育分析表明，这些分离株的基因来自中国家禽的H6和H9N2亚型AIVs。这些新型重配病毒在小鼠中表现出中度致病性，并且无需事先适应就能在小鼠中复制。鉴于本研究中从鸡中分离出新型重配H6N6病毒，这些鸡可能在新型重配H6N6 AIVs的产生中发挥重要作用，这些结果强调了持续监测在家禽中传播的H6N6 AIVs的必要性。
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