State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Zhejiang, 310003, Hangzhou, China.
Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Virol J. 2018 Oct 24;15(1):164. doi: 10.1186/s12985-018-1063-y.
The H6N1 subtype of avian influenza viruses (AIVs) can infect people with an influenza-like illness; the H6N1 viruses possess the ability for zoonotic transmission from avians into mammals, and possibly pose a threat to human health.
In 2017, live poultry markets (LPMs) in Zhejiang Province were surveyed for AIVs. To better understand the genetic relationships between these strains from Eastern China and other AIVs, all gene segments of these strains were sequenced and compared with sequences available in GenBank. In this study, we analyzed the receptor-binding specificity, antigenic characteristics, and pathogenicity of these two H6N1 viruses.
In 2017, two H6N1 AIVs were isolated from chickens during surveillance for AIVs in LPMs in Eastern China. Phylogenetic analysis showed that these strains shared genetic characteristics from H6, H10, H1, and H4 AIVs found in ducks and wild birds in East Asia. These AIV strains were able to replicate in mice without prior adaptation.
In this study, we report the discovery of new strains of H6N1 viruses from chickens with novel gene reassortments. Our results suggest that these chickens play an important role generating novel reassortments in AIVs, and emphasize the need for continued surveillance of AIV strains circulating in poultry.
禽流感病毒（AIV）的 H6N1 亚型可引起人患流感样疾病；H6N1 病毒具有从禽类向哺乳动物传播的能力，可能对人类健康构成威胁。
2017 年，对浙江省的活禽市场（LPM）进行了 AIV 调查。为了更好地了解来自中国东部的这些菌株与其他 AIV 之间的遗传关系，对这些菌株的所有基因片段进行了测序，并与 GenBank 中可用的序列进行了比较。在这项研究中，我们分析了这两种 H6N1 病毒的受体结合特异性、抗原特征和致病性。
2017 年，在中国东部的 LPM 中对 AIV 进行监测时，从鸡中分离出了两种 H6N1 AIV。系统进化分析表明，这些菌株与东亚鸭和野鸟中发现的 H6、H10、H1 和 H4 AIV 具有遗传特征。这些 AIV 株无需预先适应即可在小鼠中复制。
在这项研究中，我们报告了从具有新型基因重排的鸡中发现新的 H6N1 病毒株。我们的结果表明，这些鸡在 AIV 中产生新型重排方面发挥着重要作用，强调需要继续监测家禽中循环的 AIV 株。
