Müller U J, Schuermann F, Dobrowolny H, Frodl T, Bogerts B, Mohr S, Steiner J
Department of Psychiatry and Psychotherapy, Otto-von-Guericke-University, Magdeburg, Germany.
Department of Psychiatry and Psychotherapy at Langenhangen, Hospitals of Hannover Region, Hannover, Germany.
Pharmacopsychiatry. 2016 Sep;49(5):199-203. doi: 10.1055/s-0042-104508. Epub 2016 Apr 21.
Despite the fact, that symptom-triggered alcohol withdrawal treatment is recommended by German guidelines on alcoholism, many hospitals continue to use fixed-schedule protocols, as they have been successfully applied for many years. This retrospective study compared all patients' records of alcohol withdrawal treatment from October 2010 to November 2011 at Magdeburg's University Department of Psychiatry (n=120). A symptom-triggered protocol with clomethiazole (AESB, n=46) was used in parallel with the existing fixed-schedule protocol with diazepam (n=74). The symptom-triggered group showed less need of pharmacological treatment duration (p<0.001) and cumulative dosage of medication compared to the fixed-schedule protocol (p<0.006). No difference was observed regarding the need of clonidine or haloperidol (to treat blood pressure derailment or delirium) and the incidence of epileptic seizures. Based on the shorter treatment duration and a similar rate of complications our department has switched to the symptom-triggered protocol to improve the quality of patient care.
尽管德国酒精中毒指南推荐采用症状触发式酒精戒断治疗，但许多医院仍继续使用固定时间表方案，因为这些方案已成功应用多年。这项回顾性研究比较了2010年10月至2011年11月在马格德堡大学精神病学系接受酒精戒断治疗的所有患者记录（n = 120）。使用氯美噻唑的症状触发方案（AESB，n = 46）与现有的使用地西泮的固定时间表方案（n = 74）并行使用。与固定时间表方案相比，症状触发组在药物治疗持续时间（p < 0.001）和药物累积剂量方面的需求较少（p < 0.006）。在可乐定或氟哌啶醇（用于治疗血压紊乱或谵妄）的需求以及癫痫发作发生率方面未观察到差异。基于较短的治疗持续时间和相似的并发症发生率，我们科室已改用症状触发方案以提高患者护理质量。
