Hanlon Paul, Brorby Gregory P, Krishan Mansi
Abbott Nutrition, Columbus, OH, USA
ToxStrategies, Inc, Richmond, CA, USA.
Int J Toxicol. 2016 May;35(3):358-70. doi: 10.1177/1091581816640262. Epub 2016 Apr 21.
Processing (eg, cooking, grinding, drying) has changed the composition of food throughout the course of human history; however, awareness of process-formed compounds, and the potential need to mitigate exposure to those compounds, is a relatively recent phenomenon. In May 2015, the North American Branch of the International Life Sciences Institute (ILSI North America) Technical Committee on Food and Chemical Safety held a workshop on the risk-based process for mitigation of process-formed compounds. This workshop aimed to gain alignment from academia, government, and industry on a risk-based process for proactively assessing the need for and benefit of mitigation of process-formed compounds, including criteria to objectively assess the impact of mitigation as well as research needed to support this process. Workshop participants provided real-time feedback on a draft framework in the form of a decision tree developed by the ILSI North America Technical Committee on Food and Chemical Safety to a panel of experts, and they discussed the importance of communicating the value of such a process to the larger scientific community and, ultimately, the public. The outcome of the workshop was a decision tree that can be used by the scientific community and could form the basis of a global approach to assessing the risks associated with mitigation of process-formed compounds.
在人类历史进程中，加工处理（如烹饪、研磨、干燥）改变了食物的成分；然而，对加工形成的化合物的认知以及降低接触这些化合物的潜在需求，却是一个相对较新的现象。2015年5月，国际生命科学研究所北美分会（ILSI北美）食品与化学安全技术委员会举办了一次关于基于风险的加工形成化合物缓解过程的研讨会。本次研讨会旨在使学术界、政府和行业就基于风险的过程达成一致，以便主动评估加工形成化合物缓解措施的必要性和益处，包括客观评估缓解措施影响的标准以及支持该过程所需的研究。研讨会参与者以国际生命科学研究所北美分会食品与化学安全技术委员会制定的决策树框架草案的形式，向专家小组提供了实时反馈，并讨论了向更广泛的科学界乃至公众传达此类过程价值的重要性。研讨会的成果是一个可供科学界使用的决策树，它可能构成评估与加工形成化合物缓解相关风险的全球方法的基础。
