[低剂量他莫昔芬治疗乳腺癌的眼科并发症]
[Ophthalmologic complications of low-dosage tamoxifen in the treatment of breast carcinoma].
作者信息
de Jong-Busnac M
出版信息
Ned Tijdschr Geneeskd. 1989 Mar 11;133(10):514-6.
PMID:2710233
Abstract
Two out of 20 patients treated for metastatic or non-metastatic breast cancer with tamoxifen (20 mg 2 dd) developed bilateral secondary tapetoretinal degeneration. In one patient in whom the medication was stopped there was still slight progression of degeneration afterwards. In the other patient tamoxifen was continued under strict ophthalmological control. The total doses have been 7.3 g and 43.8 g respectively.
摘要
20例接受他莫昔芬（20毫克，每日2次）治疗转移性或非转移性乳腺癌的患者中有2例出现双侧继发性视网膜色素上皮变性。其中1例患者停药后变性仍有轻微进展。另1例患者在严格的眼科监测下继续服用他莫昔芬。总剂量分别为7.3克和43.8克。
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