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Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference.

作者信息

Baliakas Panagiotis, Puiggros Anna, Xochelli Aliki, Sutton Lesley-Ann, Nguyen-Khac Florence, Gardiner Anne, Plevova Karla, Minga Eva, Hadzidimitriou Anastasia, Walewska Renata, McCarthy Helen, Ortega Margarita, Collado Rosa, González Teresa, Granada Isabel, Luño Elisa, Kotašková Jana, Moysiadis Theodoros, Davis Zadie, Stavroyianni Niki, Anagnostopoulos Achilles, Strefford Jonathan C, Pospisilova Sarka, Davi Frederic, Athanasiadou Anastasia, Rosenquist Richard, Oscier David, Espinet Blanca, Stamatopoulos Kostas

机构信息

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden.

Laboratori de Citogenètica Molecular Servei de Patologia Hospital del Mar, Barcelona, Spain Grup de Recerca Translacional en Neoplàsies Hematològiques, Cancer Research Program, IMIM-Hospital del Mar, Barcelona, Spain.

出版信息

Haematologica. 2016 Jul;101(7):e299-302. doi: 10.3324/haematol.2015.140202. Epub 2016 Apr 21.

DOI:10.3324/haematol.2015.140202
PMID:27102498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5004477/
Abstract
摘要

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Additional trisomies amongst patients with chronic lymphocytic leukemia carrying trisomy 12: the accompanying chromosome makes a difference.携带12号染色体三体的慢性淋巴细胞白血病患者中的额外三体：伴随的染色体有影响。
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Mutational status of is the most reliable prognostic marker in trisomy 12 chronic lymphocytic leukemia.（原文中“Mutational status of ”表述不完整，无法准确翻译完整句子。完整句子翻译可为：12号染色体三体慢性淋巴细胞白血病中的[具体突变相关内容]突变状态是最可靠的预后标志物。 ）
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本文引用的文献

1
Recurrent mutations refine prognosis in chronic lymphocytic leukemia.反复出现的突变可改善慢性淋巴细胞白血病的预后。
Leukemia. 2015 Feb;29(2):329-36. doi: 10.1038/leu.2014.196. Epub 2014 Jun 19.
2
IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications.IgG 型 CLL 具有与常见 MD 变异体不同的免疫遗传学特征：个体发生学意义。
Clin Cancer Res. 2014 Jan 15;20(2):323-30. doi: 10.1158/1078-0432.CCR-13-1993. Epub 2013 Nov 15.
3
Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data.慢性淋巴细胞白血病中的染色体易位和核型复杂性：对经典细胞遗传学数据的系统再评价。
Am J Hematol. 2014 Mar;89(3):249-55. doi: 10.1002/ajh.23618.
4
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.NOTCH1 突变可识别出慢性淋巴细胞白血病患者的一个遗传亚群，这些患者具有较高的转化风险和不良预后。
Leukemia. 2013 Apr;27(5):1100-6. doi: 10.1038/leu.2012.357. Epub 2012 Dec 6.
5
NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL.NOTCH1 突变在 12 号染色体慢性淋巴细胞白血病（CLL）中预后不良，诱导独特的转录谱，并改善 12 号染色体 CLL 的中等预后。
Haematologica. 2012 Mar;97(3):437-41. doi: 10.3324/haematol.2011.060129. Epub 2011 Dec 29.
6
Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant.12号和19号染色体三体在慢性淋巴细胞白血病中的共存仅发生于罕见的IgG阳性变异型中。
Leukemia. 2012 Jan;26(1):170-2. doi: 10.1038/leu.2011.186. Epub 2011 Jul 26.
7
Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia.基于阵列的基因组筛查在慢性淋巴细胞白血病诊断时和随访期间的应用。
Haematologica. 2011 Aug;96(8):1161-9. doi: 10.3324/haematol.2010.039768. Epub 2011 May 5.
8
Prognostic significance of serum immunoglobulin paraprotein in patients with chronic lymphocytic leukemia.血清免疫球蛋白副蛋白对慢性淋巴细胞白血病患者的预后意义。
Leuk Res. 2011 Aug;35(8):1060-5. doi: 10.1016/j.leukres.2010.12.005. Epub 2011 Jan 3.
9
Disease-specific complications of chronic lymphocytic leukemia.慢性淋巴细胞白血病的疾病特异性并发症。
Hematology Am Soc Hematol Educ Program. 2008:450-6. doi: 10.1182/asheducation-2008.1.450.
10
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia.免疫球蛋白轻链在慢性淋巴细胞白血病抗原识别和选择中的重要作用的证据。
Blood. 2009 Jan 8;113(2):403-11. doi: 10.1182/blood-2008-07-166868. Epub 2008 Oct 23.