Averett Courey, Arora Sumit, Zubair Haseeb, Singh Seema, Bhardwaj Arun, Singh Ajay P
Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA.
Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA.
Enzymes. 2014;36:175-93. doi: 10.1016/B978-0-12-802215-3.00009-4.
Honokiol is a bioactive, biphenolic phytochemical, present in the aerial parts of plants classified under the genus Magnolia. It has been an important constituent of Asian traditional medicine and is used against many ailments. Honokiol possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. Consequently, there has been immense interest in exploring its utility as a novel chemopreventive and therapeutic agent against several malignancies. In this chapter, we review the structure-function relationship of honokiol and its derivative compounds, the impact of honokiol on various phenotypes associated with cancer progression and metastasis, and its prominent molecular targets and pharmacokinetics. Clearly, the available data generate significant interest in this novel phytochemical and emerging information continues to provide strong support for its potential applicability in cancer management.
厚朴酚是一种具有生物活性的双酚类植物化学物质，存在于木兰属植物的地上部分。它一直是亚洲传统医学的重要成分，用于治疗多种疾病。厚朴酚通过靶向多种信号分子，具有强大的抗氧化、抗炎、抗血管生成和抗癌活性。因此，人们对探索其作为一种新型化学预防和治疗多种恶性肿瘤药物的效用产生了浓厚兴趣。在本章中，我们综述了厚朴酚及其衍生物的结构 - 功能关系、厚朴酚对与癌症进展和转移相关的各种表型的影响，以及其主要分子靶点和药代动力学。显然，现有数据引发了对这种新型植物化学物质的极大兴趣，并且不断涌现的信息继续为其在癌症治疗中的潜在适用性提供有力支持。
