Kim Yongjin, Pak Han Kyu, Rhee Young Ho, Park Jaiwook
Department of Chemistry, POSTECH (Pohang University of Science and Technology), Pohang 790-784, Korea.
Chem Commun (Camb). 2016 May 5;52(39):6549-52. doi: 10.1039/c6cc02063a.
The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.
在无外部氧化剂的情况下，1,2-叠氮醇的酯通过钌催化形成N-H亚胺并释放出氮气，随后酰基部分进行分子内迁移，转化为α-酰胺基酮。获得了多种α-酰胺基酮，并证明了可一锅法将其转化为相应的恶唑（或噻唑）。
