通过α-叠氮醇从醛合成偕二叠氮-卤代化合物和α-叠氮烷基酯。
Synthesis of Geminal Azido-Halo Compounds and α-Azidoalkyl Esters from Aldehydes via α-Azido Alcohols.
机构信息
Chemnitz University of Technology , Organic Chemistry, Strasse der Nationen 62, 09111 Chemnitz, Germany.
出版信息
Org Lett. 2017 Sep 15;19(18):4900-4903. doi: 10.1021/acs.orglett.7b02380. Epub 2017 Sep 6.
PMID:28876955
Abstract
α-Azido alcohols are generated by treating aldehydes with hydrazoic acid in chloroform. These adducts are transformed into geminal azido-halo compounds through the reaction with phosphorus trichloride or phosphorus tribromide, whereas α-azidoalkyl esters are isolated after interaction with acyl chlorides.
摘要
α-叠氮醇可通过在氯仿中用重氮乙酸处理醛制得。这些加合物通过与三氯化磷或三溴化磷反应转化为偕二氮卤代化合物，而与酰氯反应后则可分离出α-叠氮烷基酯。
Zotero 插件