Ye Byoung Seok, Lee Yoonju, Kwak Kichang, Park Yeong-Hun, Ham Jee Hyun, Lee Jae Jung, Shin Na-Young, Lee Jong-Min, Sohn Young H, Lee Phil Hyu
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
J Alzheimers Dis. 2016 Apr 21;52(4):1237-43. doi: 10.3233/JAD-160062.
Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).
The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients.
Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain.
After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9% versus 62.8 ± 9.0%, respectively; p = 0.001) or the NC group (61.9 ± 9.9%, p = 0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education.
PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.
在阿尔茨海默病（AD）相关痴呆和路易体痴呆（DLB）中均观察到侧脑室扩大。
研究DLB患者脑室前后径扩大程度及其与临床和神经心理学特征的相关性。
48例DLB患者、76例AD患者和45名认知正常（NC）受试者接受了脑部结构MRI检查和详细的神经心理学测试。通过视觉检查比较各组的脑室形态。后脑室扩大（PVE）定义为侧脑室颞角与枕角之间的距离与侧脑室颞角与脑枕极之间的距离之比。
在控制年龄、性别和教育程度后，DLB组的PVE高于AD组（分别为68.5±7.9%和62.8±9.0%；p = 0.001）或NC组（61.9±9.9%，p = 0.002）。然而，在控制年龄、性别和教育程度后，较高的PVE与较差的神经心理学表现无关，也与DLB组的任何临床特征无关。
PVE在DLB中比在AD和NC中更常见。然而，尚不清楚PVE如何与DLB的临床和神经心理学特征相关。
