Wolach B, Franco S, Bogger-Goren S, Drucker M, Goldwasser R A, Sadan N, Bernheim J
Department of Pediatrics, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel.
Pediatr Infect Dis J. 1989 Mar;8(3):152-5.
In a prospective study of 70 Israeli children with spotted fever the major clinical features were fever (100%), skin rash (98.5%), myalgia (54%) and vomiting (40%). Thrombocytopenia (75%) and hyponatremia (62.5%) were common, but were not associated with increased mortality. Antibodies to Rickettsia conorii were detected by the indirect immunofluorescent antibody assay. In one patient Rickettsia was grown from blood. Contacts with dogs were reported in 17 of 40 patients questioned, and in only 2 was a canine tick bite obvious. Hospitalization was required in 11 (16%) patients. There was 1 fatality. The rickettsia responsible for spotted fever in Israel appears to be an antigenic variant of R. conorii. Early recognition and treatment of this disease permits rapid eradication of the rickettsiae and facilitates complete recovery.
在一项对70名患斑疹热的以色列儿童进行的前瞻性研究中，主要临床特征为发热（100%）、皮疹（98.5%）、肌痛（54%）和呕吐（40%）。血小板减少症（75%）和低钠血症（62.5%）很常见，但与死亡率增加无关。通过间接免疫荧光抗体试验检测到抗康氏立克次体抗体。在一名患者的血液中培养出了立克次体。在接受询问的40名患者中，有17名报告与狗有接触，只有2名有明显的犬蜱叮咬痕迹。11名（16%）患者需要住院治疗。有1例死亡。在以色列引起斑疹热的立克次体似乎是康氏立克次体的一种抗原变异体。对该病的早期识别和治疗可迅速根除立克次体并促进完全康复。
