Hageman J R, McCulloch K, Hunt C E, Cobb M, Quade B, Crussi F, Pachman L
Department of Pediatrics, Children's Memorial Hospital, Chicago, IL.
Prostaglandins Leukot Essent Fatty Acids. 1989 Mar;35(3):157-64. doi: 10.1016/0952-3278(89)90118-x.
To determine whether lung injury causes increased plasma prostaglandin (PG) levels, 35 rabbits received oleic acid and 35 served as controls. Half of each group also received 4 ml/kg of Intralipid over one hour and at least five in each subgroup received indomethacin 7.5 mg/kg. Arterial and venous plasma concentrations of PGE2, 6-keto-PGF1 alpha, and PGF2 alpha-M were measured. Venous PGE2 was significantly higher in the oleic acid-injured than in the normal lung group, 1560 +/- 270 (Mean +/- SEM) versus 880 +/- 140 pg/ml (p less than .05). Plasma levels were reduced by 50% with indomethacin, but PGE2 levels remained significantly higher than in the normal lung group, 850 +/- 180 versus 480 +/- 60 for arterial (p less than .05) and 820 +/- 140 versus 480 +/- 80 for venous (p less than .05), respectively. PGF2 alpha-M levels were significantly higher in the lung injury group, 240 +/- 50 versus 50 +/- 40 pg/ml for arterial (p less than .05) and 220 +/- 50 versus 95 +/- 40 for venous (p less than .05), respectively. These lung injury-related increases in PGE2 and PGF2 alpha-M appear related both to increased pulmonary production and to decreased pulmonary clearance. With Intralipid infusion, however, arterial PGE2 increased by 500 +/- 260 pg/ml compared to baseline (p less than .05) with no change in venous PGE2, indicating in this instance that the increase in arterial PGE2 levels is related to increased pulmonary production.
为了确定肺损伤是否会导致血浆前列腺素（PG）水平升高，35只兔子接受油酸处理，35只作为对照。每组中的一半兔子还在1小时内接受4ml/kg的脂肪乳剂，每个亚组中至少有5只兔子接受7.5mg/kg的吲哚美辛。测量了动脉和静脉血浆中PGE2、6-酮-PGF1α和PGF2α-M的浓度。油酸损伤组的静脉PGE2显著高于正常肺组，分别为1560±270（均值±标准误）与880±140pg/ml（p<0.05）。吲哚美辛使血浆水平降低了50%，但PGE2水平仍显著高于正常肺组，动脉血分别为850±180与480±60（p<0.05），静脉血分别为820±140与480±80（p<0.05）。肺损伤组的PGF2α-M水平显著升高，动脉血分别为240±50与50±40pg/ml（p<0.05），静脉血分别为220±50与95±40（p<0.05）。这些与肺损伤相关的PGE2和PGF2α-M升高似乎既与肺产生增加有关，也与肺清除减少有关。然而，在输注脂肪乳剂时，动脉PGE2比基线水平升高了500±260pg/ml（p<0.05），而静脉PGE2没有变化，这表明在这种情况下，动脉PGE2水平的升高与肺产生增加有关。
