Goggin Kathy, Wexler Catherine, Nazir Niaman, Staggs Vincent S, Gautney Brad, Okoth Vincent, Khamadi Samoel A, Ruff Andrea, Sweat Michael, Cheng An-Lin, Finocchario-Kessler Sarah
Children's Mercy Hospitals and Clinics, Health Services and Outcomes Research, 2401 Gillham Road, Kansas City, MO, 64108, USA.
University of Missouri-Kansas City, School of Medicine, Kansas City, MO, USA.
AIDS Behav. 2016 Sep;20(9):2141-50. doi: 10.1007/s10461-016-1404-z.
Despite the importance of early detection to signal lifesaving treatment initiation for HIV+ infants, early infant diagnosis (EID) services have received considerably less attention than other aspects of prevention of mother to child transmission care. This study draws on baseline data from an on-going cluster randomized study of an intervention to improve EID services at six government hospitals across Kenya. Two logistic regressions examined potential predictors of "on time" (infant ≤6 weeks of age) vs. "late" (≥7 weeks) and "on time" versus "very late" (≥12 weeks) EID engagement among 756 mother-infant pairs. A quarter of the infants failed to get "on time" testing. Predictors of "on time" testing included being informed about EID by providers when pregnant, perceiving less HIV stigma, and mother's level of education. Predictors of "very late" testing (≥12 weeks of age) included not being informed about EID by providers when pregnant and living farther from services. Findings highlight the importance of ensuring that health care providers actively and repeatedly inform HIV+ mothers of the availability of EID services, reduce stigma by frequently communicating judgment free support, and assisting mothers in early planning for accessing EID services. Extra care should be focused on engaging mothers with less formal education who are at increased risk for seeking "late" EID testing. This study offers clear targets for improving services so that all HIV-exposed infants can be properly engaged in EID services, thus increasing the potential for the best possible outcomes for this vulnerable population.
尽管早期检测对于启动挽救感染艾滋病毒婴儿生命的治疗至关重要,但与预防母婴传播护理的其他方面相比,早期婴儿诊断(EID)服务受到的关注要少得多。本研究借鉴了一项正在进行的整群随机研究的基线数据,该研究旨在改善肯尼亚六家政府医院的EID服务。两项逻辑回归分析考察了756对母婴中“按时”(婴儿≤6周龄)与“延迟”(≥7周)以及“按时”与“非常延迟”(≥12周)进行EID检测的潜在预测因素。四分之一的婴儿未能获得“按时”检测。“按时”检测的预测因素包括孕期从医护人员处得知EID信息、感受到的艾滋病毒污名较少以及母亲的教育水平。“非常延迟”检测(≥12周龄)的预测因素包括孕期未从医护人员处得知EID信息以及居住距离服务机构较远。研究结果凸显了确保医护人员积极且反复地告知感染艾滋病毒的母亲EID服务的可及性、通过频繁提供无评判支持来减少污名以及协助母亲尽早规划获取EID服务的重要性。应格外关注教育程度较低的母亲,她们寻求“延迟”EID检测的风险更高。本研究为改善服务提供了明确目标,以便所有暴露于艾滋病毒的婴儿都能适当地参与EID服务,从而增加这一脆弱人群获得最佳可能结果的潜力。