Sall Abibatou, Touré Awa Oumar, Sall Fatimata Bintou, Ndour Moussa, Fall Seynabou, Sène Abdoulaye, Faye Blaise Félix, Seck Moussa, Gadji Macoura, Dièye Tandakha Ndiaye, Mathiot Claire, Reynaud Sophie, Diop Saliou, Raphaël Martine
Hematology, Cheikh Anta Diop University, Dakar, Senegal.
Hematology, Aristide Le Dantec Hospital, Dakar, Senegal.
BMC Hematol. 2016 Apr 23;16:10. doi: 10.1186/s12878-016-0051-y. eCollection 2016.
Chronic lymphocytic leukemia (CLL) is a mature B-cell neoplasm characterized by the expansion of CD5-positive lymphocytes in peripheral blood. While CLL is the most common type of leukemia in Western populations, the disease is rare in Africans. Hence, clinical and laboratory data and studies of CLL in Sub Saharan populations have been limited. The aims of this study were to analyze the characteristics of senegalese patients with CLL at the time of the diagnosis and to identify the correlation between clinical characteristics (Binet stage) with age, gender, laboratory parameters and chromosomal abnormalities.
In this study, we investigated the clinical and laboratory characteristics of CLL in Senegal. A total of 40 patients who had been diagnosed with CLL during the period from July 2011 to April 2015 in Senegal were evaluated. Cytology and immunophenotype were performed in all patients to confirm the diagnosis. The prognosis factors such as Binet staging, CD38 and cytogenetic abnormalities were studied. The statistical analysis was performed using STATA version 13 (Stata college station Texas). Each patient signed a free and informed consent form before participating in the study.
The mean age was 61 years ranged from 48 to 85. There were 31 males and only 9 females (sex ratio M : F = 3,44). At diagnosic, 82.5 % of the patients were classified as having advanced Binet stages B or C. The prognosis marker CD38 was positive in 28 patients. Cytogenetic abnormalities studied by FISH were performed in 25 patients, among them, 68 % (17 cases) had at least one cytogenetic abnormality and 28 % had 2 simultaneous cytogenetic abnormalities.
Africans may present with CLL at a younger age and our data suggest that CLL in Senegal may be more aggressive than in Western populations.
慢性淋巴细胞白血病（CLL）是一种成熟B细胞肿瘤，其特征为外周血中CD5阳性淋巴细胞增多。虽然CLL是西方人群中最常见的白血病类型，但在非洲人中这种疾病较为罕见。因此，撒哈拉以南人群中CLL的临床和实验室数据及研究有限。本研究的目的是分析塞内加尔CLL患者诊断时的特征，并确定临床特征（Binet分期）与年龄、性别、实验室参数及染色体异常之间的相关性。
在本研究中，我们调查了塞内加尔CLL的临床和实验室特征。对2011年7月至2015年4月期间在塞内加尔诊断为CLL的40例患者进行了评估。对所有患者进行了细胞学和免疫表型分析以确诊。研究了Binet分期、CD38和细胞遗传学异常等预后因素。使用STATA 13版（德克萨斯州大学站Stata公司）进行统计分析。每位患者在参与研究前均签署了自由和知情同意书。
平均年龄为61岁，范围在48至85岁之间。男性31例，女性仅9例（性别比M∶F = 3.44）。诊断时，82.5%的患者被归类为Binet晚期B或C期。预后标志物CD38在28例患者中呈阳性。对25例患者进行了荧光原位杂交（FISH）研究的细胞遗传学异常分析，其中68%（17例）至少有一项细胞遗传学异常，28%有两项同时存在的细胞遗传学异常。
非洲人患CLL的年龄可能更小，我们的数据表明塞内加尔的CLL可能比西方人群中的更具侵袭性。
