Calles Javier Adrián, Ressia Jorge Aníbal, Llabot Juan Manuel, Vallés Enrique Marcelo, Palma Santiago Daniel
PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina; Dpto Biología Bioquímica y Farmacia, Universidad Nacional del Sur, San Juan 670, 8000, Bahía Blanca, Argentina; Institute of Applied Ophthalmobiology, University of Valladolid, Paseo de Belén 17, 47011, Valladolid, Spain.
PLAPIQUI-CONICET, Universidad Nacional del Sur, Camino La Carrindanga Km 7, 8000, Bahía Blanca, Argentina; Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC), 1900, La Plata, Argentina.
Sci Pharm. 2015 Jul 29;84(1):61-72. doi: 10.3797/scipharm.1504-17. Print 2016 Jan-Mar.
New hyaluronic acid-itaconic acid films were synthesized as potential materials with biomedical applications. In this work, we explored the homogeneous cross-linking reactions of hyaluronic acid using glutaraldehyde in the presence of itaconic acid and triacetin as plasticizers. Biomechanical properties were assessed in terms of stability by measuring swelling in aqueous environments, investigating wettability using contact angle tests, and evaluating bioadhesive performance. The ductility of the materials was evaluated through stress-strain measurements and the morphology was explored by scanning electron microscopy. The results show that the incorporation of itaconic acid improved most of the desirable properties, increasing adhesiveness and reducing wettability and swelling. The use of triacetin enhanced the strength, bioadhesiveness, and ductility of the material.
新型透明质酸-衣康酸薄膜被合成出来作为具有生物医学应用潜力的材料。在这项工作中，我们探索了在衣康酸和三醋精作为增塑剂存在的情况下，使用戊二醛对透明质酸进行均相交联反应。通过测量在水性环境中的溶胀来评估生物力学稳定性，使用接触角测试研究润湿性，并评估生物粘附性能。通过应力-应变测量评估材料的延展性，并通过扫描电子显微镜探索其形态。结果表明衣康酸的加入改善了大部分所需性能，增加了粘附性并降低了润湿性和溶胀性。三醋精的使用增强了材料的强度、生物粘附性和延展性。
