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急性A型主动脉夹层手术后远端残余主动脉的术后变化:假腔通畅情况及降主动脉大小的影响

Postoperative Changes in the Distal Residual Aorta after Surgery for Acute Type A Aortic Dissection: Impact of False Lumen Patency and Size of Descending Aorta.

作者信息

Leontyev Sergey, Haag Felix, Davierwala Piroze M, Lehmkuhl Lukas, Borger Michael A, Etz Christian D, Misfeld Martin, Gutberlet Matthias, Mohr Friedrich W

机构信息

Department of Cardiac Surgery, Heart Center, University of Leipzig, Leipzig, Germany.

Department of Radiology, Heart Center, University of Leipzig, Leipzig, Germany.

出版信息

Thorac Cardiovasc Surg. 2017 Mar;65(2):90-98. doi: 10.1055/s-0036-1571813. Epub 2016 Apr 25.

Abstract

In the present study, we retrospectively identified and analyzed the factors that influenced progressive dilatation of the residual distal aorta after surgical repair for acute type A aortic dissection (acute type A).  A total of 477 patients underwent surgical repair for acute type A aortic dissection between 1995 and 2012. Postoperative and follow-up computed tomography (CT) scans of the descending aorta were available in 105 patients. We analyzed the maximum aortic diameter, total luminal area, and true luminal area of the descending thoracic and abdominal aorta.  The mean follow-up time was 4.5 ± 3 years, and the mean time interval between CT scan investigations was 2.0 ± 2.3 years. A residual dissection membrane was observed in 80 (76%) patients, with presence of a patent false lumen (FL) in 52 patients (50%) and a thrombosed FL in 28 patients (26%).Progression of aortic disease with an increase in aortic diameter greater than 10 mm was observed in 14.3% ( = 15) of patients during follow-up. The independent predictors that influenced progressive dilation of the descending aorta by 10 mm or more were postoperative descending aortic diameter greater than 40 mm ( = 0.006; odds ratio [OR], 5.6; 95% confidence interval [CI], 1.6-19) and postoperative patent FL ( = 0.002; OR, 8.5; 95% CI, 2.2-32.3).The unadjusted 1- and 5-year freedom from reoperation was 96.9 ± 2 and 80.1 ± 5%, respectively. Marfan syndrome ( = 0.006; OR, 5.2; 95% CI, 1.6-16.9) and postoperative descending aortic diameter greater than 40 mm ( = 0.07; OR, 4.1; 95% CI, 1.4-11.6) were independent predictors of aorta-related reoperations.The mean survival at 1, 5, and 8 years was 90.7 ± 3, 82.5 ± 4, and 70 ± 6%, respectively. Previous cardiac surgery was independent predictor of midterm survival (hazard ratio, 3.6; 95% CI, 1.03-2.8;  = 0.04).  A regular follow-up CT scan is mandatory to assess progressive dilatation of the distal residual aortic arch, descending thoracic, and abdominal aorta after surgical repair of acute type A dissection, particularly in patients with a patent FL, descending aortic diameter greater than 40 mm, and/or Marfan syndrome.

摘要

在本研究中,我们回顾性地确定并分析了影响急性A型主动脉夹层(急性A型)手术修复后残余远端主动脉进行性扩张的因素。1995年至2012年间,共有477例患者接受了急性A型主动脉夹层的手术修复。105例患者有降主动脉术后及随访的计算机断层扫描(CT)图像。我们分析了降主动脉和腹主动脉的最大主动脉直径、总管腔面积和真腔面积。平均随访时间为4.5±3年,CT扫描检查的平均时间间隔为2.0±2.3年。80例(76%)患者观察到残余夹层膜,52例(50%)患者存在通畅的假腔(FL),28例(26%)患者存在血栓形成的FL。随访期间,14.3%(n=15)的患者出现主动脉疾病进展,主动脉直径增加超过10mm。影响降主动脉进行性扩张10mm或更多的独立预测因素为术后降主动脉直径大于40mm(P=0.006;比值比[OR],5.6;95%置信区间[CI],1.6 - 19)和术后通畅的FL(P=0.002;OR,8.5;95%CI,2.2 - 32.3)。未经调整的1年和5年再次手术自由度分别为96.9±2%和80.1±5%。马凡综合征(P=0.006;OR,5.2;95%CI,1.6 - 16.9)和术后降主动脉直径大于40mm(P=0.07;OR,4.1;95%CI,1.4 - 11.6)是主动脉相关再次手术的独立预测因素。1年、5年和8年的平均生存率分别为90.7±3%、82.5±4%和70±6%。既往心脏手术是中期生存的独立预测因素(风险比,3.6;95%CI,1.03 - 2.8;P=0.04)。对于急性A型夹层手术修复后远端残余主动脉弓、降主动脉和腹主动脉的进行性扩张评估,定期进行随访CT扫描是必不可少的,特别是对于存在通畅FL、降主动脉直径大于40mm和/或马凡综合征的患者。

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