Gu Jin, Pan Hongda
Department of Colorectal Cancer Surgery, Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2016 Apr;19(4):366-9.
Because of the improvement of surgical technique and the widely use of multimodality therapy, more patients with rectal cancer undergo sphincter-preserving surgery. However, it has been reported that up to 90% of such patients will suffer from bowel dysfunction, ranging from increased bowel frequency to faecal incontinence or evacuatory dysfunction. This wide spectrum of symptoms after resection of the rectum has been termed anterior resection syndrome (ARS). This disordered bowel function has a substantial negative effect on quality of life, however, the causal mechanisms have not been clarified. The present review discusses the clinical manifestation, underlying mechanisms, as well as prevention and treatment strategies.
由于手术技术的改进和多模式治疗的广泛应用,越来越多的直肠癌患者接受保肛手术。然而,据报道,高达90%的此类患者会出现肠道功能障碍,从排便次数增加到大便失禁或排空功能障碍不等。直肠切除术后这种广泛的症状被称为前切除综合征(ARS)。这种肠道功能紊乱对生活质量有很大的负面影响,然而,其因果机制尚未阐明。本综述讨论了其临床表现、潜在机制以及预防和治疗策略。