Qin Ningxin, Chen Qiuju, Hong Qingqing, Cai Renfei, Gao Hongyuan, Wang Yun, Sun Lihua, Zhang Shaozhen, Guo Haiyan, Fu Yonglun, Ai Ai, Tian Hui, Lyu Qifeng, Daya Salim, Kuang Yanping
Department of Assisted Rreproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China; Shanghai JiaoTong University School of Medicine, Shanghai, People's Republic of China.
Department of Assisted Rreproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Fertil Steril. 2016 Aug;106(2):334-341.e1. doi: 10.1016/j.fertnstert.2016.04.006. Epub 2016 Apr 22.
To investigate flexibility in starting controlled ovarian stimulation at any phase of the menstrual cycle in infertile women undergoing treatment with assisted reproduction.
Retrospective cohort study.
Academic tertiary-care medical center.
PATIENT(S): At total of 150 infertile patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Ninety of the women also underwent frozen embryo transfer (FET) procedures.
INTERVENTION(S): Depending on the phase of the menstrual cycle when ovarian stimulation was started, three groups of patients were identified, namely: conventional group (ovarian stimulation started in the early follicular phase), late follicular phase group, and luteal phase group. When dominant follicles were observed, final oocyte maturation was triggered with the use of GnRH agonist and hCG. In all three groups, viable embryos were cryopreserved for subsequent transfer.
number of mature oocytes retrieved.
fertilization rate, viable embryo rate per oocyte retrieved, cancellation rate, and clinical pregnancy outcomes from FET cycles.
RESULTS(S): There were no differences in the mean number of mature oocytes retrieved in the conventional group, late follicular phase group, and luteal phase group (5.7 ± 3.6, 5.2 ± 3.7, and 5.2 ± 3.9, respectively). Similarly, no significant differences were observed in the viable embryo rate per oocyte retrieved (37.9%, 38.5%, and 43.6%), clinical pregnancy rates (41.5%, 45.5%, and 38.9%), and implantation rates (30.7%, 30.2%, and 27.1%) in the three groups.
CONCLUSION(S): All three ovarian stimulation protocols were observed to be equally effective. These results demonstrate that ovarian stimulation can be commenced on any day of the menstrual cycle.
ChiCTR-OPN-15007332.
探讨接受辅助生殖治疗的不孕女性在月经周期的任何阶段开始控制性卵巢刺激的灵活性。
回顾性队列研究。
学术性三级医疗中心。
总共150例接受体外受精（IVF）或卵胞浆内单精子注射（ICSI）治疗的不孕患者。其中90名女性还接受了冻融胚胎移植（FET）程序。
根据开始卵巢刺激时月经周期的阶段，将患者分为三组，即：传统组（卵泡早期开始卵巢刺激）、卵泡晚期组和黄体期组。当观察到优势卵泡时，使用GnRH激动剂和hCG触发最终卵母细胞成熟。在所有三组中，将存活胚胎冷冻保存以备后续移植。
获取的成熟卵母细胞数量。
受精率、每个获取的卵母细胞的存活胚胎率、取消率以及FET周期的临床妊娠结局。
传统组、卵泡晚期组和黄体期组获取的成熟卵母细胞平均数量无差异（分别为5.7±3.6、5.2±3.7和5.2±3.9）。同样，三组中每个获取的卵母细胞的存活胚胎率（37.9%、38.5%和43.6%）、临床妊娠率（41.5%、45.5%和38.9%）和着床率（30.7%、30.2%和27.1%）也无显著差异。
观察到所有三种卵巢刺激方案同样有效。这些结果表明，卵巢刺激可在月经周期的任何一天开始。
ChiCTR-OPN-15007332
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