Major D, Masson M
Union Med Can. 1989 Jan-Feb;118(1):18, 21-2.
An estimation of arterial PO2 from pulse oximetry using oxyhemoglobin dissociation curve. Forty blood specimens were drawn from umbilical arteries of the neonates having a pulse sensor attached to either foot or hand. The sensor was connected to a Nellcor-N100C in twenty cases and to an Ohmeda Biox-3700 for the remaining. Mean birth weight was 1,513 g, mean gestational age 32.4 weeks, and foetal hemoglobin ranged from 54.8 to 100%. Oxyhemoglobin dissociation curves were drawn for each arterial sample to obtain P50 and estimated PO2. The estimated PaO2 was the PO2 corresponding, on the oxyhemoglobin dissociation curve, to the pulse oximeter saturation reading. Mean difference between blood saturation and pulse oximeter saturation of 1.2% was obtained with Nellcor and of 3.9% with Ohmeda. Arterial and estimated PO2 comparison gave a mean + S.E.M. difference of 4.6 +/- 1.3 torr for all cases. This represents less than 8% error in estimating PaO2 from pulse oximetry. We suggest the following polynomial equation Y = 4250 - 10.4X + 0.069X2 for using pulse oximetry (X) to evaluate PaO2 (Y) in premature infants.
利用氧合血红蛋白解离曲线通过脉搏血氧饱和度测定法估算动脉血氧分压。从足部或手部连接有脉搏传感器的新生儿脐动脉采集了40份血样。其中20例将传感器连接到Nellcor - N100C，其余连接到Ohmeda Biox - 3700。平均出生体重为1513克，平均胎龄32.4周，胎儿血红蛋白范围为54.8%至100%。为每个动脉样本绘制氧合血红蛋白解离曲线以获得P50和估算的血氧分压。估算的动脉血氧分压是在氧合血红蛋白解离曲线上与脉搏血氧饱和度读数相对应的血氧分压。使用Nellcor时，血饱和度与脉搏血氧饱和度之间的平均差异为1.2%，使用Ohmeda时为3.9%。所有病例动脉血氧分压与估算血氧分压的比较得出平均±标准误差异为4.6±1.3托。这表明通过脉搏血氧饱和度测定法估算动脉血氧分压时误差小于8%。我们建议使用以下多项式方程Y = 4250 - 10.4X + 0.069X²，通过脉搏血氧饱和度测定值（X）来评估早产儿的动脉血氧分压（Y）。
