Arce Karla M, Pantalone Kevin M
Department of Endocrinology, Diabetes and Metabolism, Mount Sinai Medical Center, Miami Beach, FL, USA.
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
Diabetes Ther. 2016 Jun;7(2):369-75. doi: 10.1007/s13300-016-0171-1. Epub 2016 Apr 26.
Neonatal diabetes mellitus (NDM), defined as persistent hyperglycemia occurring in the first months of life, is a rare cause of hyperglycemia and is often misdiagnosed as type 1 diabetes mellitus (T1DM). Numerous reports have shown that the successful transition from insulin to sulfonylurea agents can be achieved in up to 90% of patients with NDM. However, most of the reports pertain to infants; the literature is limited regarding treatment of adults with NDM. We present our experience with a patient with permanent NDM, initially misdiagnosed as T1DM, who subsequently was successfully transitioned to oral sulfonylurea therapy after 37 years of insulin dependence.
新生儿糖尿病（NDM）定义为在生命最初几个月出现的持续性高血糖，是高血糖的罕见病因，常被误诊为1型糖尿病（T1DM）。大量报告显示，高达90%的NDM患者可成功从胰岛素过渡到磺脲类药物治疗。然而，大多数报告涉及婴儿；关于成人NDM治疗的文献有限。我们介绍了一名永久性NDM患者的治疗经历，该患者最初被误诊为T1DM，在依赖胰岛素37年后，成功过渡到口服磺脲类药物治疗。
