协调 Wnt 信号传导以实现代谢性肝区隔化。
Orchestrating Wnt signalling for metabolic liver zonation.
机构信息
Cancer Research Program of the Max Delbrueck Center for Molecular Medicine, Berlin-Buch, Germany.
出版信息
Nat Cell Biol. 2016 Apr 27;18(5):463-5. doi: 10.1038/ncb3349.
DOI:10.1038/ncb3349
PMID:27117330
Abstract
Wnt/β-catenin signalling is an important regulator of liver development, zonation and regeneration. The cell surface complex RSPO-LGR4/5-ZNF3/RNF43 is now shown to direct Wnt/β-catenin signalling in orchestrating the division of the liver into functionally distinct metabolic zones, providing insights into the mechanisms that influence organ development and regeneration.
摘要
Wnt/β-catenin 信号通路是肝脏发育、分区和再生的重要调节因子。现在已经表明，细胞表面复合物 RSPO-LGR4/5-ZNF3/RNF43 可直接指导 Wnt/β-catenin 信号通路，协调肝脏的功能区分代谢区的划分，为影响器官发育和再生的机制提供了新的见解。
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