[骨髓中造血干细胞和祖细胞的生态位]
[The niche for hematopoietic stem and progenitor cells in bone marrow].
作者信息
Omatsu Yoshiki
机构信息
Laboratory of Stem Cell Biology and Developmental Immunology,Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Japan.
出版信息
Clin Calcium. 2016 May;26(5):671-6.
PMID:27117611
Abstract
It has been hypothesized that the special microenvironments known as niches in the bone marrow play an essential role in maintaining hematopoietic stem and progenitor cells(HSPCs), and the identification of the HSPC niche has been a subject of long-standing argument. Recent studies identified candidate cells meeting the criteria for HSPC niches and the critical transcription factor of their development and maintenance.
摘要
据推测，骨髓中被称为龛的特殊微环境在维持造血干细胞和祖细胞（HSPCs）方面起着至关重要的作用，而HSPC龛的识别一直是长期争论的话题。最近的研究确定了符合HSPC龛标准的候选细胞及其发育和维持的关键转录因子。
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