安沙菌素 B-D 进一步说明了安莎霉素途径中的生物合成可塑性。
Ansalactams B-D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway.
机构信息
Department of Chemistry and Nano Science, Global Top 5 program, Ewha Womans University , Seoul 03760, Korea.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , La Jolla, California 92093-0204, United States.
出版信息
Org Lett. 2016 May 6;18(9):2256-9. doi: 10.1021/acs.orglett.6b00892. Epub 2016 Apr 27.
Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.
进一步对海洋来源的链霉菌属细菌进行化学研究，分离到安莎类酰胺 B-D（1-3），以及先前报道的代谢产物安莎类酰胺 A（4）。安莎类酰胺 B-D 是经过显著修饰的安莎霉素，代表了三个新的碳骨架，进一步说明了安莎类酰胺类化合物的生物合成可塑性。与安莎类酰胺 A 不同，安莎类酰胺 B 和 D 是五元和六元环代谢物，而安莎类酰胺 C 则具有末端羧酸的开链多烯链。
Zotero 插件