Adel Mohamad, Chang Kai-Ping
Department of Otolaryngology - Head & Neck Surgery, Chang Gung Memorial Hospital, No. 5, Fu-Hsing Street, Kwei-Shan, Tao-Yuan, 33305, Taiwan.
Department of Surgery, Al-Azhar University Hospitals in Cairo, Cairo, Egypt.
J Otolaryngol Head Neck Surg. 2016 Apr 27;45:27. doi: 10.1186/s40463-016-0139-1.
Osteoradionecrosis (ORN) is a challenging complication in patients with postirradiated nasopharyngeal carcinoma (NPC). The aim of this study was to evaluate the usage of a nasoseptal flap (NSF) after endoscopic sequestrectomy to reconstruct resultant skull base defects for the treatment of ORN.
We present our experience on the adaption of an NSF as a reconstruction method for bony clival defects after endoscopic sequestrectomy in patients with postirradiated NPC. We propose that by which the patient may be offered better and prompt surgical results in the more adequate coverage of a vascularized flap for the exposed defect and attenuate the hypoxic and inflammatory process among the NPC patients suffering from postirradiation ORN.
To our knowledge, NSF use in such an indication has not been previously reported. Consequently, we advocate its utility for the management of patients with postirradiated skull base ORN in NPC in the future.
放射性骨坏死（ORN）是鼻咽癌（NPC）放疗后患者面临的一种具有挑战性的并发症。本研究的目的是评估在内镜下死骨切除术之后使用鼻中隔瓣（NSF）修复由此产生的颅底缺损以治疗ORN的效果。
我们介绍了将NSF作为放疗后NPC患者内镜下死骨切除术后骨斜坡缺损重建方法的经验。我们认为，通过这种方法，可以为患者提供更好、更迅速的手术效果，因为带血管蒂皮瓣能更充分地覆盖暴露的缺损，并减轻放疗后ORN的NPC患者的缺氧和炎症过程。
据我们所知，此前尚未有关于NSF用于此类适应症的报道。因此，我们主张未来将其用于治疗NPC放疗后颅底ORN患者。
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