Van Lierde S, Mecucci C, Casteels-Van Daele M, Van den Berghe H
Department of Pediatrics, University Hospital Gasthuisberg, University of Leuven, Belgium.
Am J Pediatr Hematol Oncol. 1989 Spring;11(1):20-2. doi: 10.1097/00043426-198921000-00005.
A boy with acute lymphoblastic leukemia (ALL) who underwent lineage switch at relapse is reported. The second leukemia was myeloid in nature (acute myeloid leukemia, AML), characterized by predominantly My 9 positive blasts at first and at second relapse. Cytogenetic studies at second relapse revealed the translocation (9;11) (p21;q23) in all examined blasts. This is typical for myelomonocytic leukemia. The nature of the relapse and the occurrence of t(9;11) translocations in acute leukemia are discussed.
报告了一名急性淋巴细胞白血病（ALL）男孩，其在复发时发生了谱系转换。第二次白血病本质上是髓系的（急性髓系白血病，AML），首次和第二次复发时主要以My 9阳性原始细胞为特征。第二次复发时的细胞遗传学研究显示，所有检测的原始细胞中均存在易位（9；11）（p21；q23）。这是髓单核细胞白血病的典型特征。本文讨论了急性白血病复发的性质以及t（9；11）易位的发生情况。
