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浸润性导管癌患者动态对比增强MRI成像特征与世界卫生组织组织病理学分级之间的关联

Association between dynamic contrast enhanced MRI imaging features and WHO histopathological grade in patients with invasive ductal breast cancer.

作者信息

Huang Juan, Yu Jianqun, Peng Yulan

机构信息

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

出版信息

Oncol Lett. 2016 May;11(5):3522-3526. doi: 10.3892/ol.2016.4422. Epub 2016 Apr 7.

DOI:10.3892/ol.2016.4422
PMID:27123145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4840852/
Abstract

The present study aimed to investigate the dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and World Health Organization (WHO) histopathological grade in patients with invasive ductal breast cancer. A retrospective analysis on the results of DCE-MRI of 92 patients, who were diagnosed with invasive ductal breast cancer following surgery or biopsy, and these results were correlated with WHO histopathological grade. The statistical analysis demonstrated that the tumor size, shape and characteristics of early enhancement were associated with the WHO histopathological grade: The larger the lesion's long diameter, the higher the WHO histopathological grade; the WHO histopathological grades of round and oval masses were relatively lower, while those of lobulated and irregular masses were higher; and tumors with heterogeneous and ring-like enhancement exhibited higher WHO histopathological grades, while those of homogeneous enhancement were lower. The lesion's margin shape was not associated with the WHO histopathological grade. The present study demonstrates that features of DCE-MRI and WHO histopathological grade in patients with invasive ductal breast cancer are correlated, and these MRI features could be used to evaluate the biological behavior and prognosis of lesions.

摘要

本研究旨在探讨浸润性导管癌患者的动态对比增强磁共振成像（DCE-MRI）与世界卫生组织（WHO）组织病理学分级之间的关系。对92例经手术或活检确诊为浸润性导管癌患者的DCE-MRI结果进行回顾性分析，并将这些结果与WHO组织病理学分级相关联。统计分析表明，肿瘤大小、形态及早期强化特征与WHO组织病理学分级相关：病变长径越大，WHO组织病理学分级越高；圆形和椭圆形肿块的WHO组织病理学分级相对较低，而分叶状和不规则肿块的分级较高；强化不均匀及环状强化的肿瘤WHO组织病理学分级较高，而均匀强化的肿瘤分级较低。病变边缘形态与WHO组织病理学分级无关。本研究表明，浸润性导管癌患者的DCE-MRI特征与WHO组织病理学分级相关，这些MRI特征可用于评估病变的生物学行为和预后。

相似文献

[1]
Association between dynamic contrast enhanced MRI imaging features and WHO histopathological grade in patients with invasive ductal breast cancer.

Oncol Lett. 2016-5

[2]
T1-Weighted Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to Distinguish Between Concurrent Cholesterol Granuloma and Invasive Ductal Carcinoma of the Breast: A Case Report.

Am J Case Rep. 2018-5-23

[3]
Diagnostic Usefulness of Combination of Diffusion-weighted Imaging and T2WI, Including Apparent Diffusion Coefficient in Breast Lesions: Assessment of Histologic Grade.

Acad Radiol. 2018-1-12

[4]
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Jpn J Clin Oncol. 2013-4-16

[5]
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Chin Med J (Engl). 2011-6

[6]
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AJR Am J Roentgenol. 2012-10

[7]
Can imaging kinetic parameters of dynamic contrast-enhanced magnetic resonance imaging be valuable in predicting clinicopathological prognostic factors of invasive breast cancer?

Acta Radiol. 2018-7

[8]
Integration of dynamic contrast-enhanced magnetic resonance imaging and T2-weighted imaging radiomic features by a canonical correlation analysis-based feature fusion method to predict histological grade in ductal breast carcinoma.

Phys Med Biol. 2019-10-23

[9]
Correlation of MRI features and pathohistological prognostic factors in invasive ductal breast carcinoma.

Acta Clin Belg. 2017-10

[10]
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Clin Imaging. 2019-5-15

引用本文的文献

[1]
Clinical value of magnetic resonance imaging in identifying multiple cerebral gliomas from primary central nervous system lymphoma.

Oncol Lett. 2019-7

[2]
Feasibility and Diagnostic Performance of Voxelwise Computed Diffusion-Weighted Imaging in Breast Cancer.

J Magn Reson Imaging. 2018-10-16

[3]
Correlation between the dynamic contrast-enhanced MRI features and prognostic factors in breast cancer: A retrospective case-control study.

Medicine (Baltimore). 2018-7

[4]
Preoperative dynamic breast magnetic resonance imaging kinetic features using computer-aided diagnosis: Association with survival outcome and tumor aggressiveness in patients with invasive breast cancer.

PLoS One. 2018-4-12

[5]
Percentage change of primary tumor on 18F-FDG PET/CT as a prognostic factor for invasive ductal breast cancer with axillary lymph node metastasis: Comparison with MRI.

Medicine (Baltimore). 2017-8

本文引用的文献

[1]
Association between rim enhancement of breast cancer on dynamic contrast-enhanced MRI and patient outcome: impact of subtype.

Breast Cancer Res Treat. 2014-12

[2]
Review of treatment assessment using DCE-MRI in breast cancer radiation therapy.

World J Methodol. 2014-6-26

[3]
Breast cancer detection using double reading of unenhanced MRI including T1-weighted, T2-weighted STIR, and diffusion-weighted imaging: a proof of concept study.

AJR Am J Roentgenol. 2014-9

[4]
Preoperative MRI in patients with locoregional recurrent breast cancer: influence on treatment modalities.

Acad Radiol. 2014-10

[5]
Breast DCE-MRI: influence of postcontrast timing on automated lesion kinetics assessments and discrimination of benign and malignant lesions.

Acad Radiol. 2014-9

[6]
World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.

JAMA. 2013-11-27

[7]
Characteristic features and usefulness of MRI in breast cancer in patients under 40 years old: correlations with conventional imaging and prognostic factors.

Breast Cancer. 2014-5

[8]
Dynamic MRI-derived parameters for hot and cold spots: correlation with breast cancer histopathology.

J BUON. 2012

[9]
Magnetic resonance imaging patterns of tumor regression after neoadjuvant chemotherapy in breast cancer patients: correlation with pathological response grading system based on tumor cellularity.

J Comput Assist Tomogr. 2012

[10]
MRI morphological classification of ductal carcinoma in situ (DCIS) correlating with different biological behavior.

Eur J Radiol. 2011-2-5

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