MRI 形态学分类在导管原位癌（DCIS）与不同生物学行为相关性中的作用。

MRI morphological classification of ductal carcinoma in situ (DCIS) correlating with different biological behavior.

机构信息

Department of Radiology, Cancer center, Fudan University, Shanghai 200032, China.

出版信息

Eur J Radiol. 2012 Feb;81(2):214-7. doi: 10.1016/j.ejrad.2010.12.084. Epub 2011 Feb 5.

DOI:10.1016/j.ejrad.2010.12.084

PMID:21296513

Abstract

OBJECTIVE

To investigate morphological appearance of ductal carcinoma in situ of breast on MRI and to correlate the appearances with some factors.

METHODS AND MATERIALS

MRI feature of 41 DCISs were analyzed retrospectively according to ACR BI-RADS, twenty-three of the 41 were pure DCIS and 18 were DCIS with microinvasion (DCIS-MI). The shape was categorized as mass lesion and non-mass-like lesion. The shape was correlated with histological grade, ER status and expression of e-erbB2 as well as pure DCIS or DCIS-MI.

RESULTS

Percentage of high grade in non-mass-like lesion was higher than that in mass type group, Average size of tumor in group of high grade, negative ER status and positive c-erbB2 expression were larger than that in non-high grade, positive ER status and negative c-erbB2 expression. Comparing pure DCIS and DCIS-MI, high grade in DCIS-MI was significantly higher than that in pure DCIS, Average size of DCIS-MI was larger than that in pure DCIS. Percentage of non-mass-like lesion was higher in DCIS-IM than that in pure DCIS, the difference was marginally significant.

CONCLUSION

DCIS can be classified as mass type and non-mass-like type morphologically on MRI. The two types reflect different biological behavior.

摘要

目的

探讨乳腺导管原位癌（DCIS）的 MRI 形态表现，并与部分因素相关联。

方法与材料

回顾性分析了 41 例 DCIS 的 MRI 特征，依据 ACR BI-RADS 进行分类，其中 23 例为单纯 DCIS，18 例为伴有微浸润的 DCIS（DCIS-MI）。将形态分为肿块样病变和非肿块样病变。分析形态与组织学分级、ER 状态、e-erbB2 的表达以及单纯 DCIS 或 DCIS-MI 之间的相关性。

结果

非肿块样病变中高级别比例高于肿块样病变，高级别组、ER 阴性和 c-erbB2 阳性组的肿瘤平均大小大于非高级别、ER 阳性和 c-erbB2 阴性组。与单纯 DCIS 相比，DCIS-MI 中的高级别比例显著更高，DCIS-MI 的肿瘤平均大小也更大。DCIS-MI 中非肿块样病变的比例高于单纯 DCIS，但差异无统计学意义。