Jasson J, Lefèvre G, Tallet F, Talafre M L, Legagneux F, Conseiller C
Département d'Anesthésie-Réanimation, Groupe Hospitalier Cochin-Maternités, Paris.
Ann Fr Anesth Reanim. 1989;8(1):12-8. doi: 10.1016/s0750-7658(89)80136-4.
A study was carried out to assess the effects of oral sodium citrate on the pH and volume of gastric content in 52 unpremedicated women undergoing elective Caesarean section under general anaesthesia. The patients were randomly assigned to two groups: group T (n = 26) without antacids and group C (n = 26) receiving orally 30 ml of 0.3 M sodium citrate solution 5 min before induction of anaesthesia. After tracheal intubation, a size 18 double lumen naso-gastric tube was introduced. The gastric content was sampled 10 min (n = 52), 50 min (n = 52) and 80 min (n = 24) later. Before extubation, the stomach was completely emptied and the naso-gastric tube removed. On each sampling time, the pH was measured with a digital pHmeter; a search for biliary salts (pyloric reflux) was carried out with thin layer chromatography; the volume of the gastric content was measured using the phenol red dilution method. At 10 min, none patient in group C had a gastric pH less than 2.5, in the opposite to 92% of patients in the control group T. The alkalinizing effect of the citrate lasted throughout the evaluation time. The mean pH was respectively 5.3 +/- 1.07, 5.23 +/- 1.2 and 5.53 +/- 1.3 at 10, 50 and 80 min in group C (controls: 1.9 +/- 0.7; 2.49 +/- 1.3; 2.40 +/- 0.61). However, the citrate solution increased significantly the volume of the gastric content. It was respectively 51.1 +/- 29.9 ml, 79.15 +/- 70.9 ml and 32.9 +/- 22.1 ml; 29.6 +/- 28.5 ml; 26.6 +/- 10.9 ml).(ABSTRACT TRUNCATED AT 250 WORDS)
一项研究旨在评估口服柠檬酸钠对52例未用术前药、接受全身麻醉下择期剖宫产手术的女性胃内容物pH值和容量的影响。患者被随机分为两组：T组（n = 26）不使用抗酸剂，C组（n = 26）在麻醉诱导前5分钟口服30 ml 0.3 M柠檬酸钠溶液。气管插管后，插入一根18号双腔鼻胃管。分别在10分钟（n = 52）、50分钟（n = 52）和80分钟（n = 24）后采集胃内容物样本。拔管前，将胃完全排空并拔除鼻胃管。在每个采样时间，用数字pH计测量pH值；用薄层色谱法检测胆盐（幽门反流）；用酚红稀释法测量胃内容物的容量。在10分钟时，C组没有患者胃pH值低于2.5，而对照组T组有92%的患者胃pH值低于2.5。柠檬酸盐的碱化作用在整个评估期间持续存在。C组在10、50和80分钟时的平均pH值分别为5.3±1.07、5.23±1.2和5.53±1.3（对照组：1.9±0.7；2.49±1.3；2.40±0.61）。然而，柠檬酸钠溶液显著增加了胃内容物的容量。分别为51.1±29.9 ml、79.15±70.9 ml和32.9±22.1 ml；29.6±28.5 ml；26.6±10.9 ml。（摘要截短至250字）
