Department of Paediatrics, University Malaya Medical Centre, Malaysia.
Ann Acad Med Singap. 2016 Feb;45(2):61-8.
This study aimed to quantify and investigate factors affecting the health-related quality of life (HRQoL) in children with biliary atresia (BA) living with their native livers.
A cross-sectional study on the HRQoL using the PedsQL4.0 generic core scales in children with BA aged between 2 to 18 years followed up at the University Malaya Medical Centre (UMMC) in Malaysia was conducted. Two groups, consisting of healthy children and children with chronic liver disease (CLD) caused by other aetiologies, were recruited as controls.
Children with BA living with their native livers (n = 36; median (range) age: 7.4 (2 to 18) years; overall HRQoL score: 85.6) have a comparable HRQoL score with healthy children (n = 81; median age: 7.0 years; overall HQRoL score: 87.4; P = 0.504) as well as children with CLD (n = 44; median age: 4.3 years; overall score: 87.1; P = 0.563). The HRQoL of children with BA was not adversely affected by having 1 or more hospitalisations in the preceding 12 months, the presence of portal hypertension, older age at corrective surgery (>60 days), a lower level of serum albumin (≤34 g/L) or a higher blood international normalised ratio (INR) (≥1.2). Children who had liver transplantation for BA did not have a significantly better HRQoL as compared to those who had survived with their native livers (85.4 vs 85.7, P = 0.960).
HRQoL in children with BA living with their native livers is comparable to healthy children.
本研究旨在量化并探讨影响伴有自身肝脏的胆道闭锁（BA）儿童健康相关生活质量（HRQoL）的因素。
对在马来西亚大学医学中心（UMMC）接受随访的 2 至 18 岁 BA 儿童使用 PedsQL4.0 通用核心量表进行 HRQoL 的横断面研究。招募了两组儿童作为对照组，一组为健康儿童，另一组为因其他病因导致的慢性肝病（CLD）儿童。
伴有自身肝脏的 BA 儿童（n=36；中位数（范围）年龄：7.4（2 至 18）岁；整体 HRQoL 评分：85.6）的 HRQoL 评分与健康儿童（n=81；中位数年龄：7.0 岁；整体 HQRoL 评分：87.4；P=0.504）以及 CLD 儿童（n=44；中位数年龄：4.3 岁；整体评分：87.1；P=0.563）相当。在过去 12 个月内有 1 次或多次住院、门静脉高压、矫正手术时年龄较大（>60 天）、血清白蛋白水平较低（≤34g/L）或国际标准化比值（INR）较高（≥1.2）不会对 BA 儿童的 HRQoL 产生不利影响。与那些伴有自身肝脏的 BA 儿童相比，接受肝移植治疗的 BA 儿童的 HRQoL 并没有显著改善（85.4 与 85.7，P=0.960）。
伴有自身肝脏的 BA 儿童的 HRQoL 与健康儿童相当。
