Maryakhina Valeriya S, Ovechkin Maxim V
Orenburg State University, 13 Pobedy St, Orenburg, 460018, Russia.
Lasers Med Sci. 2016 Jul;31(5):979-83. doi: 10.1007/s10103-016-1943-6. Epub 2016 Apr 28.
The results of differences of wool oxygen status of healthy and cancer carrier mice with spontaneous cancer tumor are represented herein. The investigation was carried out by electronic microscopy and laser-flash photolysis. In the work, two types of breast tumors were researched. Small tumor (nearly 0.5 ÷ 1 cm) was detected by palpation and was well encapsulated. Large tumor was operated when tumor had been disintegrated. It is shown that wool of healthy mouse has dense structure; external layer with large scales is pronounced. At the time, wool of mice with cancer tumor is thinner; external and internal layers are destroyed. Length of scales is shorter. There is difference even when tumor diameter is small. Oxygen concentration increases for cancer present, and it is related to reactive oxygen species rising within external layer. Reactive oxygen species have most distribution in general oxygen concentration in external cell layer. At the time, its increase in internal layer is insignificant. The obtained results can be used to improve optical techniques of biomedical diagnostics of cancer diseases.
本文展示了患有自发性癌肿瘤的健康小鼠和癌症携带小鼠羊毛氧状态的差异结果。该研究通过电子显微镜和激光闪光光解进行。在这项工作中，研究了两种类型的乳腺肿瘤。通过触诊检测到小肿瘤（近0.5÷1厘米），且包膜良好。当肿瘤已经崩解时对大肿瘤进行了手术。结果表明，健康小鼠的羊毛结构致密；具有大鳞片的外层明显。与此同时，患有癌肿瘤的小鼠的羊毛更细；外层和内层被破坏。鳞片长度较短。即使肿瘤直径很小时也存在差异。癌症存在时氧浓度增加，这与外层内活性氧的增加有关。活性氧在外部细胞层的总氧浓度中分布最多。与此同时，其在内层的增加不显著。所获得的结果可用于改进癌症疾病生物医学诊断的光学技术。
