根管内N2糊剂改变犬牙髓组织后的细胞介导免疫反应。
Cell-mediated immune response to dog pulp tissue altered by N2 paste within the root canal.
作者信息
Block R M, Sheats J B, Lewis R D, Fawley J
出版信息
Oral Surg Oral Med Oral Pathol. 1978 Jan;45(1):131-42. doi: 10.1016/0030-4220(78)90236-0.
After pulpal extirpation of twenty teeth in each of four dogs, these animals were primarily immunized intramuscularly with the dogs' own pulp (three dogs) altered by N2 paste and saline solution with pulp (one dog). A fifth dog was used as a control for skin tests. Secondary immunizations were accomplished via the root canal every 7 days over a 28-day period. Cell-mediated skin tests reactions demonstrated less of a response to the N2 paste alone than when the dogs' pulp was altered with this material. In vitro analysis of cell-mediated immune response (lymphocyte proliferation) showed a marked response to the pulp altered by N2 paste as compared to the saline-treated pulp (P less than 0.002). Therefore, dogs' pulp tissue became antigenically altered by the N2 material, recognized by the host, and a specific cell-mediated lymphocyte proliferation resulted.
在对四只狗的每只狗的二十颗牙齿进行牙髓摘除后，这些动物首先通过肌肉注射用N2糊剂改变的自身牙髓（三只狗）和含有牙髓的盐溶液（一只狗）进行初次免疫。第五只狗用作皮肤试验的对照。在28天的时间内，每隔7天通过根管进行二次免疫。细胞介导的皮肤试验反应表明，单独对N2糊剂的反应比对用这种材料改变狗的牙髓时的反应要小。与盐水处理的牙髓相比，对细胞介导的免疫反应（淋巴细胞增殖）的体外分析显示，对用N2糊剂改变的牙髓有明显反应（P小于0.002）。因此，狗的牙髓组织被N2材料抗原性改变，被宿主识别，并导致特异性细胞介导的淋巴细胞增殖。
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