对根管内丁香酚改变的犬牙髓组织的细胞介导免疫反应。
Cell-mediated immune response to dog pulp tissue altered by eugenol within the root canal.
作者信息
Block R M, Lewis R D, Sheats J B, Fawley J
出版信息
Oral Surg Oral Med Oral Pathol. 1978 Mar;45(3):452-63. doi: 10.1016/0030-4220(78)90532-7.
After pulpal extirpation of twenty teeth in each of four dogs, these animals were primarily immunized intramuscularly with the dog's own pulp (three dogs) and saline solution with pulp (one dog). A fifth dog was used as a control for skin tests. Secondary immunizations were accomplished via the root canal every 7 days over a 28-day period. Cell-mediated skin-test reactions demonstrated less of a response to the eugenol alone than when the dog's pulp was incubated with this material. In vitro analysis of cell-mediated immune response (lymphocyte proliferation) showed a marked response to the pulp altered by eugenol as compared to the saline-treated pulp (p less than 0.004). Therefore, dog's pulp tissue became antigenically altered by eugenol material, recognized by the host, and a specific cell-mediated lymphocyte proliferation resulted.
在对四只狗每只拔除20颗牙齿的牙髓后，这些动物主要通过肌肉注射自身牙髓（三只狗）和含牙髓的盐溶液（一只狗）进行初次免疫。第五只狗用作皮肤试验的对照。在28天的时间里，每隔7天通过根管进行二次免疫。细胞介导的皮肤试验反应表明，单独使用丁香酚时的反应比狗牙髓与该材料一起孵育时的反应小。细胞介导免疫反应（淋巴细胞增殖）的体外分析显示，与盐水处理的牙髓相比，经丁香酚改变的牙髓有明显反应（p小于0.004）。因此，狗的牙髓组织被丁香酚材料抗原性改变，被宿主识别，并导致特异性细胞介导的淋巴细胞增殖。
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