Hemet J, Metayer J, Lemoine F, Laquerriere A, Elmaleh A M
Travail du Laboratoire d'Anatomie Pathologique, Hôpital Charles Nicolle, Rouen.
Ann Pathol. 1989;9(1):33-7.
Microscopic findings, observed in 58 colonic biopsies, have been described by the authors during transient ischemic colitis. One of these lesions, closely associated with the diagnosis and named patchy tubular atrophy, was considered as a marker for ischemia. Patchy tubular atrophy was observed at the beginning of the disease, and was regularly associated with normal and necrotic areas. Three morphological aspects characterized this condition: --non secretory glandular crypts covered with rudimentary basophilic epithelium, --crypts regularly distributed in a geometrical pattern with intact connective spaces, --absence of interstitial inflammatory infiltrate, and presence of fibrinous thrombosis with extravasation of erythrocytes. This morphologic pattern was specific enough to rule ou the other inflammatory or trophic bowel diseases. Therefore patchy tubular atrophy, observed during transient ischemic colitis, was considered by authors as a distinct entity.
作者描述了在58例结肠活检中观察到的微观表现，这些表现出现于短暂性缺血性结肠炎期间。其中一种病变与诊断密切相关，被命名为斑片状肾小管萎缩，被视为缺血的标志物。斑片状肾小管萎缩在疾病初期即可观察到，且常与正常区域和坏死区域相关。这种情况有三个形态学特征：——非分泌性腺管隐窝被原始嗜碱性上皮覆盖，——隐窝以几何图案规则分布，结缔组织间隙完整，——无间质炎性浸润，存在纤维蛋白血栓形成并伴有红细胞外渗。这种形态学模式具有足够的特异性，可排除其他炎症性或营养性肠道疾病。因此，作者认为短暂性缺血性结肠炎期间观察到的斑片状肾小管萎缩是一种独特的病变。
