Lynch L, Berkowitz R L
Mount Sinai Medical Center, Department of Obstetrics, Gynecology, and Reproductive Science, New York, New York 10029.
Am J Perinatol. 1989 Apr;6(2):237-9. doi: 10.1055/s-2007-999584.
Neonates with trisomy 18 are usually growth retarded at birth, and delayed growth has been ultrasonigraphically detected antenatally during the second and third trimesters in fetuses with this aneuploidy. We examined the growth patterns of five fetuses with trisomy 18 during the first trimester and compared them with a group of 16 normal control subjects. The crown-rump length of all trisomy 18 fetuses was at least 5 days smaller than expected (mean, 8.2 days; range 5 to 11 days), whereas only two controls had a similar delay (p less than 0.005). We conclude that in patients in whom gestational age is certain by other parameters, significant growth delay detected during the first trimester may be a useful marker for trisomy 18.
18三体综合征的新生儿出生时通常生长发育迟缓，在孕期第二和第三阶段，超声检查已在患有这种非整倍体的胎儿中检测到产前生长延迟。我们检查了5例18三体综合征胎儿在孕早期的生长模式，并将其与16名正常对照受试者进行了比较。所有18三体综合征胎儿的头臀长度比预期至少小5天（平均8.2天；范围5至11天），而只有两名对照者有类似延迟（p小于0.005）。我们得出结论，在通过其他参数确定孕周的患者中，孕早期检测到的显著生长延迟可能是18三体综合征的一个有用标志物。
