一种用于回顾性估算个体在休息和体育锻炼期间对高代谢和低代谢溶剂的呼吸摄入量的方法。
A method for the retrospective estimation of the individual respiratory intake of a highly and a poorly metabolising solvent during rest and physical exercise.
作者信息
Opdam J J, Smolders J F
机构信息
Coronel Laboratory, Faculty of Medicine, University of Amsterdam, The Netherlands.
出版信息
Br J Ind Med. 1989 Apr;46(4):250-60. doi: 10.1136/oem.46.4.250.
A method for the retrospective estimation of the individual respiratory intake was tested. The method is based on system dynamics. Subjects were exposed simultaneously to the poorly metabolising solvent tetrachloroethene (PER, perchloroethylene) and the highly metabolising trichloroethene (TRI) at rest, 30, and 65 watt physical exercise. The time courses of the alveolar concentration (Calv) of both PER and TRI were measured. A retrospective estimation of the individual intake of PER could be carried out up to 400 hours after exposure with 10-20% accuracy, irrespective of the level of exercise. The estimates of the intake of TRI are less accurate. The Calv in the 1-15 hours postexposure permits the estimation of the intake of TRI within a mean error of 25% for most subjects. For men the method may be applied up to 48 hours after exposure within 20% error. For women the intake estimates showed a poor accuracy with the use of Calv beyond the day of exposure.
对一种回顾性估算个体呼吸摄入量的方法进行了测试。该方法基于系统动力学。受试者在静息状态、30瓦和65瓦体育锻炼时，同时接触代谢缓慢的溶剂四氯乙烯（PER，全氯乙烯）和代谢迅速的三氯乙烯（TRI）。测量了PER和TRI的肺泡浓度（Calv）随时间的变化过程。无论运动水平如何，在接触后长达400小时内，均可对个体PER摄入量进行回顾性估算，准确率达10%-20%。TRI摄入量的估算准确性较低。对于大多数受试者而言，接触后1至15小时内的Calv可用于估算TRI摄入量，平均误差为25%。对于男性，该方法在接触后48小时内应用时误差在20%以内。对于女性，使用接触当天之后的Calv进行摄入量估算时，准确性较差。
Zotero 插件