Shapiro R, Gilbert H, Skeel R T, Kagan A R, Jacobs M, Senyszyn J, Chan P, Nussbaum H
Rev Interam Radiol. 1977 Oct;2(4):191-7.
The authors reviewed 181 patients who received local radiation therapy for the prevention or control of extramedullary disease resulting from acute leukemia. 126 had acute lymphocytic leukemia and 55 had acute granulocytic leukemia. They were treated over a 18-year period of time with different forms of chemotherapy. Most had not received prophylactic CNS radiation therapy. Patients were evaluated for local control until death or hematologic relapse intervened. More than 80% of patients with clinical ALL meningeal leukemia had a successful response to doses over 1000 rads. This same response was not apparent in AML. More than 80% of clinical non-CNS extra medullary leukemia was controlled with doses of 600 rads or greater. Only one patient with extra-medullary relapse is still alive. The authors feel that lower preventative doses of radiation to the CNS are compatible with similar control rates, based on their own data and other suggestive data.
作者回顾了181例接受局部放射治疗以预防或控制急性白血病所致髓外疾病的患者。其中126例为急性淋巴细胞白血病，55例为急性粒细胞白血病。他们在18年的时间里接受了不同形式的化疗。大多数患者未接受预防性中枢神经系统放射治疗。对患者进行局部控制评估，直至死亡或血液学复发。超过80%的临床急性淋巴细胞白血病脑膜白血病患者对超过1000拉德的剂量有成功反应。这种反应在急性髓细胞白血病中并不明显。超过80%的临床非中枢神经系统髓外白血病通过600拉德或更高剂量得到控制。只有一名髓外复发患者仍然存活。基于他们自己的数据和其他提示性数据，作者认为较低剂量的中枢神经系统预防性放射与相似的控制率是相容的。
