Department of Internal Medicine, Metabolic Disorders and Hypertension, University of Medical Sciences, Szamarzewskiego Str. 82/84, 60-569 Poznań, Poland.
Department of Physiology, Biochemistry and Hygiene, University School of Physical Education, Królowej Jadwigi Str. 27/39, 61-871 Poznań, Poland.
Biomed Pharmacother. 2016 May;80:1-7. doi: 10.1016/j.biopha.2016.02.017. Epub 2016 Mar 12.
Obesity is a risk factor of nonalcoholic fatty liver disease. Although the standard therapy for obesity involves physical exercise, well-planned studies of the changes in liver function in response to different exercise intensities in obese subjects are scarce. The aim of the present study was to examine a question of how does exercise mode affect the liver function.
44 women with abdominal obesity were randomized into two exercise groups: endurance (group A) and endurance-strength (group B). Women in each group exercised for 60min 3 times/week for a 3-month period. Markers of liver function: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), alkaline phosphatase (ALP) activities, and bilirubin levels were quantified.
We found significant differences in ALT (p<0.01) and AST (p<0.05) activities between group A and B after training exercise. Blood ALT and AST tended to decrease in group B, increase in group A. Significant reduction in serum GGT level after exercise in both groups was observed (p<0.001, group A; p<0.01, group B). Neither endurance nor endurance-strength exercise led to changes in serum ALP activity and total or direct bilirubin level. However, endurance-strength training resulted in significant decreases in serum indirect bilirubin (p<0.05). Strong positive correlations between serum indirect bilirubin and body mass (r=0.615; p=0.0085) and BMI (r=0.576; p=0.0154) were found after endurance-strength exercise (group B).
The mode of exercise does matter: endurance-strength exercise led to a greater improvement, compared to endurance exercise, in the liver function in women with abdominal obesity.
肥胖是非酒精性脂肪肝的一个危险因素。虽然肥胖的标准治疗方法包括体育锻炼，但针对肥胖患者不同运动强度对肝功能变化的研究很少有精心设计的。本研究旨在探讨运动方式如何影响肝功能。
44 名腹部肥胖的女性被随机分为两组运动组：耐力组（A 组）和耐力-力量组（B 组）。每组女性每周运动 3 次，每次 60 分钟，持续 3 个月。测定肝功能标志物：血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、γ-谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）活性和胆红素水平。
我们发现训练后 A 组和 B 组 ALT（p<0.01）和 AST（p<0.05）活性有显著差异。B 组的血液 ALT 和 AST 有下降趋势，A 组则相反。两组的血清 GGT 水平在运动后均显著降低（p<0.001，A 组；p<0.01，B 组）。耐力或耐力-力量运动均未导致血清 ALP 活性和总胆红素或直接胆红素水平的变化。然而，耐力-力量训练导致血清间接胆红素显著降低（p<0.05）。在耐力-力量训练（B 组）后，血清间接胆红素与体重（r=0.615；p=0.0085）和 BMI（r=0.576；p=0.0154）呈强正相关。
运动方式确实很重要：与耐力运动相比，腹部肥胖女性的耐力-力量运动使肝功能得到了更大的改善。
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