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美国的阿片类药物流行问题。

The Opioid Epidemic in the United States.

作者信息

Wilkerson Richard Gentry, Kim Hong K, Windsor Thomas Andrew, Mareiniss Darren P

机构信息

Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA.

Department of Emergency Medicine, University of Maryland School of Medicine, 110 South Paca Street, 6th Floor, Suite 200, Baltimore, MD 21201, USA.

出版信息

Emerg Med Clin North Am. 2016 May;34(2):e1-e23. doi: 10.1016/j.emc.2015.11.002. Epub 2016 Feb 17.

DOI:10.1016/j.emc.2015.11.002
PMID:27133253
Abstract

There is an epidemic of opioid abuse. This article discusses the history of opioid use. Abusers of opioids are at great risk of harm. There have been increasing legislative efforts to curb this abuse and we present a review of the current state of these laws. Naloxone has made a profound impact in the care of these patients if they present for medical care early enough. This paper discusses naloxone pharmacodynamics, its use in the medical setting, and how its use is now being expanded to include nontraditional providers with take home naloxone programs.

摘要

存在阿片类药物滥用的流行情况。本文讨论了阿片类药物的使用历史。阿片类药物滥用者面临极大的伤害风险。为遏制这种滥用现象,立法方面的努力不断增加,我们对这些法律的现状进行了综述。如果这些患者能尽早寻求医疗护理,纳洛酮在他们的护理中产生了深远影响。本文讨论了纳洛酮的药效学、其在医疗环境中的使用,以及其使用如今如何扩展到包括通过纳洛酮带回家计划的非传统提供者。

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The Opioid Epidemic in the United States.美国的阿片类药物流行问题。
Emerg Med Clin North Am. 2016 May;34(2):e1-e23. doi: 10.1016/j.emc.2015.11.002. Epub 2016 Feb 17.
2
The US Opioid Crisis: Current Federal and State Legal Issues.美国阿片类药物危机:当前联邦和州的法律问题。
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Responding to the Opioid Epidemic in the United States.应对美国的阿片类药物流行问题。
Phys Ther. 2018 Mar 1;98(3):147-148. doi: 10.1093/ptj/pzx120.
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The epidemic of prescription opioid abuse, the subsequent rising prevalence of heroin use, and the federal response.处方阿片类药物滥用的流行、随后海洛因使用的患病率上升以及联邦政府的应对措施。
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Prescription opioid abuse: Problems and responses.处方阿片类药物滥用:问题与应对措施
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The opioid epidemic: impact on orthopaedic surgery.阿片类药物流行:对骨科手术的影响。
J Am Acad Orthop Surg. 2015 May;23(5):267-71. doi: 10.5435/JAAOS-D-14-00163.
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Assessment of the trends in medical use and misuse of opioid analgesics from 2004 to 2011.2004年至2011年阿片类镇痛药医疗使用和滥用趋势评估。
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Misuse of Prescription and Illicit Drugs in Middle Adulthood in the Context of the Opioid Epidemic.滥用处方和非法药物与阿片类药物流行背景下的中年期。
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Controlled Substance Prescribing Patterns--Prescription Behavior Surveillance System, Eight States, 2013.受控物质处方模式 - 处方行为监测系统,八个州,2013 年。
MMWR Surveill Summ. 2015 Oct 16;64(9):1-14. doi: 10.15585/mmwr.ss6409a1.

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J Patient Cent Res Rev. 2025 Apr 22;12(2):76-81. doi: 10.17294/2330-0698.2103. eCollection 2025 Spring.
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Communication-efficient federated learning of temporal effects on opioid use disorder with data from distributed research networks.利用分布式研究网络的数据进行通信高效的阿片类药物使用障碍时间效应联合学习。
J Am Med Inform Assoc. 2025 Apr 1;32(4):656-664. doi: 10.1093/jamia/ocae313.
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What makes an epidemic a disaster: the future of epidemics within the EM-DAT International Disaster Database.
是什么让疫情成为灾难:EM-DAT国际灾害数据库中的疫情未来。
BMC Public Health. 2025 Jan 3;25(1):21. doi: 10.1186/s12889-024-21026-2.
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Adolescent oral oxycodone self-administration disrupts neurobehavioral and neurocognitive development.青少年口服羟考酮自我给药会破坏神经行为和神经认知发育。
Neuropharmacology. 2024 Nov 1;258:110064. doi: 10.1016/j.neuropharm.2024.110064. Epub 2024 Jul 7.
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Evolution of an epidemic: Understanding the opioid epidemic in the United States and the impact of the COVID-19 pandemic on opioid-related mortality.疫情演变:了解美国的阿片类药物流行情况以及 COVID-19 大流行对阿片类药物相关死亡率的影响。
PLoS One. 2024 Jul 9;19(7):e0306395. doi: 10.1371/journal.pone.0306395. eCollection 2024.
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A Diagram of the Social-Ecological Conditions of Opioid Misuse and Overdose.阿片类药物滥用和过量使用的社会生态条件图。
Int J Environ Res Public Health. 2023 Oct 20;20(20):6950. doi: 10.3390/ijerph20206950.
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βγ G-proteins, but not regulators of G-protein signaling 4, modulate opioid-induced respiratory rate depression.βγ G蛋白而非G蛋白信号调节因子4,可调节阿片类药物引起的呼吸频率降低。
Front Physiol. 2023 Apr 6;14:1043581. doi: 10.3389/fphys.2023.1043581. eCollection 2023.
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Feasibility of a Citizen-driven Hackathon to Increase Public Engagement and Solutions to Address the Opioid Crisis.由公民驱动的黑客马拉松活动在提高公众参与度及解决阿片类药物危机方面的可行性。
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