Haufe S, Witt H, Engeli S, Kaminski J, Utz W, Fuhrmann J C, Rein D, Schulz-Menger J, Luft F C, Boschmann M, Jordan J
Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany.
Metanomics Health GmbH, Berlin, Germany.
Nutr Metab Cardiovasc Dis. 2016 Jul;26(7):637-642. doi: 10.1016/j.numecd.2016.03.013. Epub 2016 Apr 7.
BACKGROUND & AIMS: Amino acids may interfere with insulin action, particularly in obese individuals. We hypothesized that increased circulating branched-chain and aromatic amino acids herald insulin resistance and ectopic fat storage, particularly hepatic fat accumulation.
We measured fasting branched-chain and aromatic amino acids (tryptophan, tyrosine, and phenylalanine) by mass spectrometry in 111 overweight to obese subjects. We applied abdominal magnetic resonance imaging and spectroscopy to assess adipose tissue distribution and ectopic fat storage, respectively. Plasma branched-chain amino acids concentrations were related to insulin sensitivity and intrahepatic fat independent from adiposity, age and gender, but not to abdominal adipose tissue or intramyocellular fat.
In weight stable overweight and obese individuals, branched-chain amino acid concentrations are specifically associated with hepatic fat storage and insulin resistance.
氨基酸可能会干扰胰岛素作用，尤其是在肥胖个体中。我们推测，循环中支链氨基酸和芳香族氨基酸水平升高预示着胰岛素抵抗和异位脂肪储存，特别是肝脏脂肪堆积。
我们采用质谱法对111名超重至肥胖受试者的空腹支链氨基酸和芳香族氨基酸（色氨酸、酪氨酸和苯丙氨酸）进行了测量。我们应用腹部磁共振成像和波谱分别评估脂肪组织分布和异位脂肪储存情况。血浆支链氨基酸浓度与胰岛素敏感性和肝脏内脂肪相关，且不受肥胖、年龄和性别的影响，但与腹部脂肪组织或肌细胞内脂肪无关。
在体重稳定的超重和肥胖个体中，支链氨基酸浓度与肝脏脂肪储存及胰岛素抵抗存在特定关联。
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