Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana.
Department of Obstetrical, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
J Clin Endocrinol Metab. 2020 Oct 1;105(10):e3747-56. doi: 10.1210/clinem/dgaa377.
Recent evidence has related circulating branch-chained amino acids (BCAAs) to ectopic fat distribution.
To investigate the associations of changes in plasma BCAAs induced by weight-loss diet interventions with hepatic fat and abdominal fat, and potential modification by different diets.
DESIGN, SETTING, AND PARTICIPANTS: The current study included 184 participants from the 2-year Preventing Overweight and Using Novel Dietary Strategies (POUNDS Lost) trial with repeated measurements on plasma BCAAs, hepatic fat, and abdominal fat over 2 years.
Repeated measurements of hepatic fat, abdominal fat distribution, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT).
Over 2 years, a decrease in total plasma BCAAs was significantly associated with improvement in hepatic density (a marker for hepatic fat; P = 0.02) and reductions in abdominal fat, including VAT, SAT, and TAT (all P < 0.05) in the main analyses. Additionally, we observed that decreases in BCAAs were associated with decreased insulin, homeostasis model assessment of insulin resistance, and triglycerides, independent of weight loss (all P < 0.05). Moreover, we found that dietary protein intake significantly modified the relation between changes in total plasma BCAAs and hepatic density at 6 months (Pinteraction = 0.01). Participants with a larger decrease in total BCAAs showed a greater increase in hepatic density when consuming a high-protein diet, compared with those with a smaller decrease or increase in total BCAAs.
Our findings indicate that weight-loss diet-induced decrease in plasma BCAAs is associated with reductions of hepatic and abdominal fat. In addition, dietary protein intake may modify these associations.
最近的证据表明循环支链氨基酸（BCAAs）与异位脂肪分布有关。
研究减肥饮食干预引起的血浆 BCAAs 变化与肝脂肪和腹部脂肪的相关性，并探讨不同饮食的潜在影响。
设计、地点和参与者：本研究纳入了来自为期 2 年的预防超重和使用新型饮食策略（POUNDS Lost）试验的 184 名参与者，在 2 年内对血浆 BCAAs、肝脂肪和腹部脂肪进行了重复测量。
肝脂肪、腹部脂肪分布的重复测量，包括内脏脂肪组织（VAT）、皮下脂肪组织（SAT）和总脂肪组织（TAT）。
在 2 年内，总血浆 BCAAs 的减少与肝密度的改善（肝脂肪的标志物；P=0.02）以及腹部脂肪的减少显著相关，包括 VAT、SAT 和 TAT（所有 P<0.05）。此外，我们还观察到，BCAAs 的减少与胰岛素、稳态模型评估的胰岛素抵抗和甘油三酯的降低独立于体重减轻有关（所有 P<0.05）。此外，我们发现膳食蛋白质摄入量显著改变了总血浆 BCAAs 变化与 6 个月时肝密度之间的关系（P 交互=0.01）。与总 BCAAs 减少较小或增加的参与者相比，当摄入高蛋白饮食时，总 BCAAs 减少较大的参与者肝密度增加更大。
我们的研究结果表明，减肥饮食引起的血浆 BCAAs 减少与肝脂肪和腹部脂肪的减少有关。此外，膳食蛋白质摄入量可能会影响这些关联。
