老年人艰难梭菌感染的粪便微生物群移植
Fecal microbiota transplant for Clostridium difficile infection in older adults.
作者信息
Tauxe William M, Haydek John P, Rebolledo Paulina A, Neish Emma, Newman Kira L, Ward Angela, Dhere Tanvi, Kraft Colleen S
机构信息
Emory University School of Medicine, Atlanta, GA, USA.
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
出版信息
Therap Adv Gastroenterol. 2016 May;9(3):273-81. doi: 10.1177/1756283X15622600. Epub 2015 Dec 31.
BACKGROUND
The objective of this study was to describe the safety of fecal microbiota transplant (FMT) for Clostridium difficile infection (CDI) among older adults.
METHODS
We performed a case review of all FMT recipients aged 65 or older treated at Emory University Hospital, a tertiary care and referral center for Georgia and surrounding states.
RESULTS
CDI resolved in 27 (87%) of 31 respondents, including three individuals who received multiple FMTs. Among four whose CDI was not resolved at follow up, three respondents did well initially before CDI recurred, and one individual never eradicated his CDI despite repeating FMT. During the study, five deaths and eight serious adverse events requiring hospitalization were reported within the study group during the follow-up period. Fecal transplant was not a causative factor in these events. The most common adverse event reported in 4 (13%) of 31 respondents was subjective worsening of arthritis.
CONCLUSION
FMT is a generally safe and effective treatment option for older adults with CDI.
背景
本研究的目的是描述老年艰难梭菌感染（CDI）患者粪便微生物群移植（FMT）的安全性。
方法
我们对在埃默里大学医院接受治疗的所有65岁及以上FMT受者进行了病例回顾，该医院是佐治亚州及周边州的三级医疗和转诊中心。
结果
31名受访者中有27名（87%）的CDI得到缓解，其中包括三名接受多次FMT的患者。在随访时CDI未缓解的四名患者中，三名受访者最初情况良好，随后CDI复发，一名患者尽管重复进行FMT，但其CDI从未根除。在研究期间，随访期内研究组报告了五例死亡和八起需要住院治疗的严重不良事件。粪便移植不是这些事件的致病因素。31名受访者中有4名（13%）报告的最常见不良事件是关节炎主观症状加重。
结论
FMT是老年CDI患者普遍安全有效的治疗选择。
Zotero 插件