1Department of Physiology, 2Center for Muscle Biology, and 3College of Medicine, University of Kentucky, Lexington, KY.
Exerc Sport Sci Rev. 2016 Jul;44(3):110-5. doi: 10.1249/JES.0000000000000082.
Muscle hypertrophy occurs when the rate of protein synthesis exceeds the rate of degradation. A main factor determining the rate of protein synthesis is ribosome abundance or translational capacity. The production of ribosomes is a primary determinant of translational capacity. Based on studies from our laboratory, we propose the novel hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy.
当蛋白质合成的速度超过降解速度时,就会发生肌肉肥大。决定蛋白质合成速度的一个主要因素是核糖体的丰度或翻译能力。核糖体的产生是翻译能力的主要决定因素。基于我们实验室的研究,我们提出了一个新的假设,即核糖体生物发生对于骨骼肌肥大是必要的。