Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland; University of Basel, Faculty of Science, Mattenstrasse 26, CH-4058 Basel, Switzerland.
Curr Opin Biotechnol. 2016 Aug;40:139-148. doi: 10.1016/j.copbio.2016.04.005. Epub 2016 Apr 29.
Synthetic biology applies engineering principles to biological systems and reprograms living cells to perform novel and improved functions. In this review, we first provide an update of common tools and design principles that enable user-defined control of mammalian cell activities with spatiotemporal precision. Next, we demonstrate some examples of how engineered mammalian cells can be developed towards biomedical solutions in the context of real-world problems.
合成生物学将工程原理应用于生物系统，并对活细胞进行重新编程，以实现新颖和改进的功能。在这篇综述中，我们首先提供了常用工具和设计原则的最新更新，这些工具和设计原则使我们能够以时空精度实现对哺乳动物细胞活动的用户定义控制。接下来，我们展示了一些示例，说明如何针对实际问题，将经过工程改造的哺乳动物细胞开发为生物医学解决方案。
