Custead M R, Weng H Y, Childress M O
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN, USA.
Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.
Vet Comp Oncol. 2017 Sep;15(3):808-819. doi: 10.1111/vco.12222. Epub 2016 May 2.
The study hypothesis is that higher doses of metronomic (low-dose) chlorambucil will improve outcome without significantly worsening adverse events (AE). Retrospectively, 88 dogs were screened to assess for tolerability and response to chlorambucil utilizing retrospective and prospective data sets, comparing metronomic oral daily doses 4, 6 and 8 mg m . There were 78 and 70 dogs in the tolerability and efficacy portions, respectively. The severity of gastrointestinal (GI) AE was significantly worse, and time to development of GI events was significantly shorter at 6 mg m than at 4 mg m (both P < 0.001). Chlorambucil was discontinued earlier in the dogs treated at the 6 mg m doses than in the dogs treated at 4 mg m (P = 0.015). Thrombocytopenia occurred significantly earlier at 8 mg m than at 4 mg m (P = 0.017). Higher doses of metronomic (low-dose) chlorambucil did not provide improved responses and were associated with more AE.
该研究假设为，更高剂量的节拍式（低剂量）苯丁酸氮芥将改善预后，而不会显著加重不良事件（AE）。通过回顾性和前瞻性数据集，对88只犬进行回顾性筛查，以评估其对苯丁酸氮芥的耐受性和反应，比较4、6和8mg/m的口服每日节拍式剂量。耐受性和疗效部分分别有78只和70只犬。胃肠道（GI）不良事件的严重程度在6mg/m时显著更严重，且胃肠道事件发生的时间在6mg/m时显著短于4mg/m（均P<0.001）。在6mg/m剂量治疗的犬中，苯丁酸氮芥比在4mg/m剂量治疗的犬更早停药（P=0.015）。血小板减少症在8mg/m时比在4mg/m时显著更早出现（P=0.017）。更高剂量的节拍式（低剂量）苯丁酸氮芥并未提供更好的反应，且与更多不良事件相关。
