Harper A, Blackwood L
Institute of Veterinary Sciences, University of Liverpool, Liverpool, Wirral CH64 7TE, UK.
J Small Anim Pract. 2017 Apr;58(4):227-230. doi: 10.1111/jsap.12635. Epub 2017 Jan 30.
The objective of this study was to assess the incidence of toxicity in a group of cancer-bearing dogs treated with metronomic chemotherapy.
Retrospective review of dogs treated with metronomic doses of cyclophosphamide: between 5 and 15 mg/m /day or every other day for treatment of neoplasia.
Of the 65 dogs included, there were signs of, mostly mild, toxicity in 32 (49%). The most common toxicities were sterile haemorrhagic cystitis (n=16) and gastrointestinal disorders (n=12). Median time to development of sterile haemorrhagic cystitis was 110 days (range 7 to 686 days). Four dogs developed suspected bacterial infections during treatment.
Metronomic cyclophosphamide is generally well-tolerated in dogs but the incidence of sterile haemorrhagic cystitis in this study is higher than previously reported. Regular urinalysis is recommended for all dogs receiving cyclophosphamide chemotherapy, as early detection of haemorrhagic cystitis may prevent development of more serious disease.
本研究的目的是评估接受节拍化疗的一组患癌犬的毒性发生率。
回顾性分析接受环磷酰胺节拍剂量治疗的犬：剂量为5至15毫克/平方米/天或隔天给药，用于治疗肿瘤。
纳入的65只犬中，32只（49%）出现毒性迹象，大多为轻度。最常见的毒性反应是无菌性出血性膀胱炎（n = 16）和胃肠道疾病（n = 12）。无菌性出血性膀胱炎出现的中位时间为110天（范围7至686天）。4只犬在治疗期间发生疑似细菌感染。
环磷酰胺节拍疗法在犬中一般耐受性良好，但本研究中无菌性出血性膀胱炎的发生率高于先前报道。建议对所有接受环磷酰胺化疗的犬定期进行尿液分析，因为早期发现出血性膀胱炎可预防更严重疾病的发生。
