Johnco Carly, McGuire Joseph F, McBride Nicole M, Murphy Tanya K, Lewin Adam B, Storch Eric A
Department of Pediatrics, University of South Florida, USA; Centre for Emotional Health, Department of Psychology, Macquarie University, Sydney, Australia.
Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA.
J Affect Disord. 2016 Aug;200:204-11. doi: 10.1016/j.jad.2016.04.027. Epub 2016 Apr 23.
This study examined the incidence and clinical correlates of suicidal ideation (SI) in youth with tic disorders (TD). The independent contribution of tics, anxiety, depressive and externalizing symptoms on SI severity in youth with TD was assessed.
Participants were 75 treatment-seeking youth with a TD (N=75) aged 6-18. Participants completed diagnostic assessments, clinician-ratings, self- and parent-report measures of emotional functioning and the presence and/or severity of suicidal ideation.
Based on youth-report, 61% of youth endorsed at least some symptoms of SI, and 8% endorsed symptoms that exceeded the clinically significant cut-off. Parents reported SI in 11% of cases, with generally poor agreement between parent- and youth-report. Suicidal ideation correlated with higher anxiety, depressive and externalizing symptoms, affective lability, and with poorer distress tolerance and overall functioning. Anxiety, depressive and externalizing symptoms showed an independent relationship with SI. Tic severity was not associated with SI. Rather, higher tic severity was associated with an increase in anxiety symptoms, which in turn, was associated with greater SI severity.
Cross-sectional data limits causal conclusions. Diagnosis was based on unstructured assessments by expert clinicians, including consensus diagnosis, rather than structured clinical interviews.
Around 8-11% of youth with TD experienced SI. Tic severity did not have any direct influence on SI, however the presence of comorbid anxiety and depressive symptoms significantly increases this risk. Results suggest that it is psychiatric comorbidity, rather than tics themselves, that predispose youth with tic disorders to increased risk of suicidality.
本研究调查了抽动障碍(TD)青少年自杀观念(SI)的发生率及其临床相关因素。评估了抽动、焦虑、抑郁和外化症状对TD青少年SI严重程度的独立影响。
参与者为75名6 - 18岁寻求治疗的TD青少年(N = 75)。参与者完成了诊断评估、临床医生评分、自我及家长报告的情绪功能测量以及自杀观念的存在情况和/或严重程度。
根据青少年报告,61%的青少年认可至少一些SI症状,8%认可超过临床显著临界值的症状。家长报告11%的病例存在SI,家长与青少年报告之间的一致性普遍较差。自杀观念与更高的焦虑、抑郁和外化症状、情感不稳定以及更低的痛苦耐受性和整体功能相关。焦虑、抑郁和外化症状与SI呈独立关系。抽动严重程度与SI无关。相反,更高的抽动严重程度与焦虑症状增加相关,而焦虑症状又与更高的SI严重程度相关。
横断面数据限制了因果结论。诊断基于专家临床医生的非结构化评估,包括共识诊断,而非结构化临床访谈。
约8 - 11%的TD青少年经历过SI。抽动严重程度对SI没有直接影响,然而共病焦虑和抑郁症状的存在显著增加了这种风险。结果表明,是精神共病,而非抽动本身,使患有抽动障碍的青少年自杀风险增加。